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NCT Number: NCT06903026

PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome

Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at present. A recent study on a small sample size (N=29) highlighted an association between obstructive sleep apnea syndrome and amnesic stroke. Our study seeks to confirm or refute these results on a larger cohort (N=200-250). A better understanding of the pathophysiological processes involved would open up new therapeutic avenues.

Recruiting

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Key information

Conditions

Transient Global Amnesia Amnesia Amnesia, Transient Global Apnea Brain Diseases Central Nervous System Diseases Dyssomnias Memory Disorders Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Sleep Apnea Syndromes Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de Neurologie - CHU de Strasbourg - France

Strasbourg, 67091, France

Location status: Recruiting

Location contact

Benjamin CRETIN, MD

CONTACT

[email protected]

33 3 88 12 86 34

Benjamin CRETIN, MD

PRINCIPAL_INVESTIGATOR

Elisabeth RUPPERT, MD

SUB_INVESTIGATOR

Erik SAULEAU, Statistician

SUB_INVESTIGATOR

Solène CHARBONNIER, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria:
The stroke must have been documented and reported by a competent witness present during the stroke.
Anterograde amnesia during the stroke.
Absence of vigilance, personality, and cognitive disorders other than memory disorders (aphasia, apraxia, etc.).
Absence of focal neurological symptoms during the episode and its aftermath.
Absence of epileptic manifestations.
Resolution of the episode in less than 24 hours.
Exclusion of patients with a history of recent head trauma or active epilepsy (undergoing regular treatment or having experienced a seizure in the last 2 years).
Subjects who have not expressed opposition to the reuse of their data for scientific research purposes.

Exclusion criteria

Patients who have expressed opposition to the retrospective reuse of their data for scientific research purposes.
Patients with active epilepsy
Patients with recent head trauma
Patients with an MMS < or equal to 25
Subject under guardianship or curatorship
Subject under judicial protection

Treatment and study plan

Primary outcomes

To assess the prevalence of obstructive sleep apnea syndrome in patients who have experienced an amnestic stroke.

Time frame: Within the last 2 years

Presence or absence of obstructive sleep apnea syndrome reported by a witness present during the stroke.

Study contacts

Contact information is provided by the study sponsor or research team.

Benjamin CRETIN, MD

CONTACT

[email protected]

33 3 88 12 86 34

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Acronym: PROTOS

Important dates

Study start: 2023
Primary completion: 2025
Study completion: 2025
First posted: Mar 30, 2025
Registry last updated: Mar 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting