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OpenTrials
Completed

NCT Number: NCT01837056

Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

Investigate the prevalence of Toxoplasma gondii and Toxocara canis in Uveitis

* serum antibody to T. gondii and T. canis * PCR with peripheral blood for T. gondii and T. canis * PCR with aqueous humor for T. gondii and T. canis * Clinical manifestation of patient with uveitis

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Key information

Conditions

Uveitis Eye Diseases Uveal Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

Consecutive patients with uveitis are enrolled in Nune Eye Hospital.

Serum ELISA

  • IgM,IgG antibody to Toxoplasma gondii
  • IgG antibody to Toxocara canis

PCR

  • PCR with serum and aqueous humor to Toxoplasma gondii
  • PCR with serum and aqueous humor to Toxocara canis Clinical characteristics
  • visual acuity
  • intraocular pressure (IOP)
  • location and degree of inflammation
  • other fundus findings were recorded

questionnaire

  • environment, occupation
  • pet ownership, exposure to animal
  • history of eating raw liver of animal, raw beef or any other raw flesh of animal.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with uveitis

Exclusion criteria

  • Patients with history of major ophthalmic surgery within 6 months
  • antiviral, antifungal or antiparasitic therapy within 6 months

Treatment and study plan

Primary outcomes

  1. Number of patients with positive result for serum antibody to Toxoplasma gondii and Toxocara canis

    Time frame: at baseline

    proportion of patients with seropositive for Toxoplasma gondii and Toxocara canis among patients

Secondary outcomes

  1. Number of patients with positive PCR with peripheral blood and aqueous humor to Toxoplasma gondii and Toxocara canis

    Time frame: at baseline

    Proportion of patient with positive PCR to Toxoplasma gondii and Toxocara canis

Other outcomes

  1. location of inflammation and fundus finding

    Time frame: at baseline

    location of inflammation

    • anterior or posterior or panuveitis

    fundus finding

    • granuloma in macular or periphery retina
    • pigmentation

  2. Demographic characteristics

    Time frame: at baseline

    • Gender
    • Residence
    • Pet ownership
    • Habit of eating uncooked meat

Sponsors and collaborators

Lead sponsor

National Institute of Health, Korea

Other Gov

Registry information

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Apr 22, 2013
Registry last updated
Apr 22, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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