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Completed

NCT Number: NCT01457963

Prevalence of Pulmonary Embolism in ICU

The primary objective of this study was to estimate the prevalence of PE among consecutive ICU patients receiving MV who required thoracic computed tomography (CT) with contrast agent injection, regardless of whether PE was suspected clinically. The secondary objectives were to assess the association between PE and DVT, to identify risk factors for VTE, and to determine the outcome of VTE.

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Key information

Conditions

Pulmonary Embolism Cardiovascular Diseases Deep Venous Thrombosis Embolism Embolism and Thrombosis Lung Diseases Respiratory Tract Diseases Thrombosis Vascular Diseases Venous Thrombosis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University hospital of grenoble

Grenoble, 38043, France

About this study

Background: Pulmonary embolism (PE) produces nonspecific or minimal symptoms in mechanically ventilated (MV) patients, leading to underdiagnosis. We estimated the prevalence of PE and associations with deep vein thrombosis (DVT) among MV patients.

Methods: Consecutive MV patients who required thoracic computed tomography (CT) in a single ICU. Compression ultrasound of the four limbs was performed within 48 hours of inclusion. Curative anticoagulation therapy was given immediately after PE diagnosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all patients requiring invasive MV and thoracic contrast-enhanced CT for any reason

Exclusion criteria

  • a diagnosis of PE before ICU admission,
  • allergy to contrast agents,
  • and age younger than 18 years.

Treatment and study plan

Primary outcomes

  1. Find a pulmonary embolism on the CT scan

    Time frame: CT scan at the day of inclusion

    TO estimate the prevalence of PE among consecutive ICU patients receiving MV who required thoracic computed tomography (CT) with contrast agent injection, regardless of whether PE was suspected clinically.

Secondary outcomes

  1. To find thrombus on compression ultrasound (CUS) of the four limbs

    Time frame: CUS within 48 hours after the CT scan

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Official study title

Pulmonary Embolism in Mechanically Ventilated Patients Requiring Computed Tomography: Prevalence, Risk Factors and Outcome

Acronym: PEICU

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
Oct 24, 2011
Registry last updated
Oct 24, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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