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OpenTrials
Completed

NCT Number: NCT07195110

Prevalence of Periodontitis in Egyptian Multiple Sclerosis Patients.

The goal of this observational study is to explore the association between multiple sclerosis and periodontal disease in a sample of Egyptian population

The main question it aims to answer is:

• Is there an association between MS and periodontal disease Participants already diagnosed with multiple sclerosis. A conventional oral examination will be held on a dental unit, filling charts and patients' acceptance to participate in the survey.

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Key information

About this study

Periodontal disease is a chronic inflammatory condition leading to progressive destruction of the supporting structures of the teeth. Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that may share common inflammatory pathways with periodontal disease. Recent evidence suggests that systemic inflammation may influence the severity and progression of both conditions.

This study will recruit participants already diagnosed with MS and assess their periodontal status using standard clinical parameters, including clinical attachment loss (CAL), probing pocket depth, and bleeding on probing measured at six sites per tooth using a periodontal probe. Data will be collected through a conventional oral examination in a dental unit, and results will be compared to evaluate the prevalence and potential association between MS and periodontal disease within this population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with MS
  • Adult patients ≥ 18 years old.
  • Patients providing an informed consent

Exclusion criteria

  • Periodontal therapy within the last 3 months.
  • Having surgical therapy or undergoing orthodontic treatment
  • Smokers
  • Pregnant females
  • Patients with systemic condition know to impact the periodontal condition other than MS (eg. Diabetes Mellitus)
  • Patients having more than 5 lost teeth

Treatment and study plan

Primary outcomes

  1. Prevalence of periodontal disease as assessed by clinical periodontal parameters ( clinical attachment loss )within the study population.

    Time frame: Baseline

    CAL will be measured as the distance from the cementoenamel junction (CEJ) to the base of the periodontal pocket using a periodontal probe at six sites per tooth. Mean CAL will be calculated for each participant to assess periodontal tissue destruction.

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Prevalence of Periodontal Disease Among Egyptian Patients With Multiple Sclerosis S: A Cross Sectional Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 26, 2025
Registry last updated
Mar 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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