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Completed

NCT Number: NCT04114565

Prevalence of Major Depression Among Immigrants in Santiago, Chile

The general aim of this study is to explore the prevalence of major depressive disorder and the use of mental health services in the immigrant populations in the Metropolitan Region of Santiago, Chile.

The hypotheses are:

1. A healthy immigrant effect will be observed in the studied population by which their prevalence of major depressive disorder will be lower than the prevalence in the general Chilean population. 2. A significant association will be observed between the loss of socio-economic position after migration and a greater probability of major depressive disorder. 3. A significant association will be observed between the report of victimization experience(s) in the previous year and a greater probability of major depressive disorder. 4. A significant association will be observed between financial difficulties and a greater probability of major depressive disorder.

The sampling framework of the Chilean National Institute of Statistics (INE) from the 2016 Census will be used for the purpose of this research. The sampling units are as follows:

1. Primary sampling units (PSUs): conglomerates or groups of adjoining houses, organized in spatial blocks (200 households on average) 2. Secondary sampling units (SSUs): individual households within each of the conglomerates selected in the first stage 3. Final sampling units: persons meeting the study's inclusion criteria Multi-stage random probability sampling involving a 3-stage sampling design will be used - first, the sampling of the primary sampling units (PSUs); second, the sampling of households within the selected PSUs and finally, the random sampling of a household member.

Participants (n=1,100) will then take part in a 45-minute interview. This interview will be a household survey using the modular version of the Composite International Diagnostic Interview (WHO-CIDI) looking at exploring a broad spectrum of factors traditionally associated with increased risk of affective disorders:

1. Sociodemographics 2. Finance 3. Variation in socioeconomic position 4. Experience of victimization 5. Discrimination 6. Experience of childhood adversity

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Key information

Conditions

Major Depressive Disorder Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Pontificia Universidad Catolica de Chile

Santiago, RM, 7550139, Chile

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Country of birth other than Chile
  • Time since arrival to Chile: 3 months

Exclusion criteria

  • Unable to understand Spanish

Treatment and study plan

Primary outcomes

  1. Major Depressive Disorder

    Time frame: baseline

    Assessed using the World Health Organisation Composite International Diagnostic Interview (WHO-CIDI)

  2. Any affective/mood disorder

    Time frame: baseline

    Assessed using the WHO-CIDI

  3. Suicidal ideation, plans and attempts

    Time frame: baseline

    Assessed using the WHO-CIDI

  4. Depressive symptoms

    Time frame: baseline

    Assessed using the nine-item Patient Health Questionnaire (PHQ-9).

    The PHQ-9 score can range from 0 to 27, with the following severity scores: 0-4 None; 5-9 Mild; 10-14 Moderate; 15-19 Moderate to Severe; 20-27 Severe.

  5. Anxiety symptoms

    Time frame: baseline

    Assessed using the Generalized Anxiety Disorder 7-item scale (GAD-7).

    The GAD-7 score can range from 0 to 21, with the following severity scores: 0-4 None; 5-9 Mild; 10-14 Moderate; 15-21 Severe.

Secondary outcomes

  1. Mental wellbeing

    Time frame: baseline

    Assessed using the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS).

    The 14 Items are scored on a range from 1 to 5, providing a total score between 14 and 70 with higher values indicating higher mental well-being.

  2. Mental health service use

    Time frame: baseline

    Assessed using items of the Services Module of the WHO-CIDI

  3. Hazardous/harmful drinking

    Time frame: baseline

    Assessed using the Alcohol Use Disorders Identification Test (AUDIT)

Sponsors and collaborators

Lead sponsor

Pontificia Universidad Catolica de Chile

Other

Collaborators

  • Fondo Nacional de Desarrollo Científico y Tecnológico, Chile

Registry information

Official study title

The Santiago Immigrant Wellbeing Study (STRING): Prevalence of Mood Disorders Among Immigrants in Santiago, Chile

Acronym: STRING

Important dates

Study start
2019
Primary completion
2019
Study completion
2020
First posted
Oct 3, 2019
Registry last updated
Jul 31, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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