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NCT Number: NCT04949737

Prevalence of Helicobacter Pylori Infection and Gastric Cancer in the West Indies

Estimating the prevalence of Helicobacter Pylori infection in newly diagnosed stomach cancers in the West-Indies will help to understand the epidemiology of this cancer, which is over-incident in the West Indies compared to France. In addition, the constitution of a biobank (tumor tissues, healthy tissues and serum) will allow to set up in a second time etiological studies to identify other risk factors in particular in connection with the exposure to environmental pollutants to adapt the prevention measures.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Martinique

Fort-de-France, 97261, Martinique

Location status: Recruiting

Location contact

Amélie BIRON

PRINCIPAL_INVESTIGATOR

Mickaelle ROSE

CONTACT

[email protected]

+596596592623

Thierry BORTUZZO

PRINCIPAL_INVESTIGATOR

About this study

In the Antilles-Guyana, gastric cancer affects approximately 80 men and women each year in Guadeloupe and Martinique, and 20 in French Guiana. It is more frequent than in France and represents 4.5% of cancers in men in Martinique, 5.3% in Guadeloupe and 5.7% in French Guyana. It is the 3rd most common cancer site in men in Guadeloupe and Martinique, and the 4th in French Guiana. In women, it is the 3rd most frequent cancer in Martinique and the 4th in Guadeloupe, whereas it is less frequent in French Guiana.

Studies are needed to estimate this prevalence in the general population and in cancer patients. The prevalence of Helicobacter pylori infection is not well known in the general population in the Caribbean and when gastric cancer is diagnosed, the bacterium is rarely tested.

Dietary habits in our regions are characterized by a high consumption of salt (salted), meat and smoked fish. These dietary habits, common to some Southeast Asian countries, could partly explain the high incidence of stomach cancer observed. But environmental risk factors could also be involved.

Patients referred to gastroenterology with a suspected endoscopic diagnosis of gastric cancer will be offered to participate in the study after the fibroscopy has been performed and their consent will be obtained for the use of diagnostic specimen remains for research purposes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient over 18 years of age, residing for at least 6 months in Martinique, with a primary diagnosis of gastric cancer
  • Patient having read the information note and having signed the consent to participate in the study
  • Patient with social security coverage

Exclusion criteria

  • Refusal to participate
  • Patient who could not answer the questionnaires
  • Patient not affiliated to a social security system
  • Patient not fluent in French
  • Patient under legal protection (legal protection, guardianship, curators, etc.)

Treatment and study plan

Helicobacter Pylori detection

Biological

Biopsies will be sent to the referral anatomopathology laboratory. The search for Helicobacter pylori will be performed by immunohistochemistry. An additional blood sample for serological testing will be taken during the initial workup.

Additional data will be collected through a questionnaire.

Primary outcomes

  1. Estimation of the prevalence of Helicobacter pylori

    Time frame: At baseline

    Helicobacter Pylori has detected by immunohistochemistry in the stomach of patients with gastric cancer.

Study contacts

Contact information is provided by the study sponsor or research team.

Clarisse JOACHIM-CONTARET

CONTACT

[email protected]

+596596559674

Mickaelle ROSE

CONTACT

[email protected]

+596596592623

Sponsors and collaborators

Lead sponsor

University Hospital Center of Martinique

Other

Registry information

Official study title

Prevalence of Helicobacter Pylori Infection and Gastric Cancer in the West Indies: Helico-MQ Interventional Study

Acronym: Hélico-MQ

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Jul 2, 2021
Registry last updated
Mar 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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