Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease

Celiac disease (CD) and eosinophilic esophagitis (EE) are distinct diseases of the gastrointestinal tract with specific clinico-pathological characteristics. In recent years, in the literature, several children who underwent upper gastrointestinal endoscopy for suspected CD, which was confirmed histologically, were also found to have coexistent EE. There are reports of coexistent CD and EE. We would like to see the prevalence of EE in children with CD and the prevalence of CD in children with EE in our population, and to do so would like to review medical records. Our objectives are to determine if children with celiac disease have a high prevalence of eosinophilic esophagitis.and to determine if children with eosinophilic esophagitis have increased risk of developing celiac disease.

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Key information

Conditions

Celiac Disease Digestive System Diseases Eosinophilia Eosinophilic Esophagitis Esophageal Diseases Esophagitis Gastroenteritis Gastrointestinal Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Intestinal Diseases Leukocyte Disorders Malabsorption Syndromes Metabolic Diseases Nutritional and Metabolic Diseases

Age range

2 year–21 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Seen in the Pediatric Gastroenterology clinic at St. John Hospital & Medical Center during study time frame
Age 2-21 years old
Diagnosed with CD or EE or both based on the endoscopic and histopathological findings .

Exclusion criteria

Gastroesophageal reflux diagnosed by PH probe.
History of chemical ingestion

Treatment and study plan

Primary outcomes

Review of histopathology reports of esophageal biopsies to record the number of eosinophils per high power field.

Time frame: Retrospective chart review study, no contact made with patients, so no patient time is required, expected average of 2 years

Sponsors and collaborators

Lead sponsor

St. John Health System, Michigan

Other

Registry information

Official study title

Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease and Prevalence of Celiac Disease in Children With Eosinophilic Esophagitis in a Tertiary Community Hospital

Important dates

Study start: 2011
Primary completion: 2013
First posted: Jul 15, 2014
Registry last updated: Jul 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed