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View Trial DetailsNCT Number: NCT04625374
The main objective for investigators is to determine the prevalence of moderate to severe chronic pain in the adult population 6 months after consultation in the emergency department for acute pain (less than 7 days old) and severe pain assessed at admission and defined as greater than or equal to 6/10 by the numerical pain scale.
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Notify Me18 year and older
All sexes
Observational
CHU Pellegrin, Bordeaux, France
The presence of pain is the most frequent reason for a patient to visit the emergency department. the investigators know that severe acute pain can be a risk factor for developing chronic pain.
Chronic pain is a symptom, devoid of biological utility, that persists despite the absence of nociceptive stimulus, even after a reasonable period of time that would have allowed the tissue lesion to heal. It is therefore a public health problem with a negative impact on patients' lives.
Chronic pain has been studied in anesthesia and surgery in recent years. In 2006, a study showed the appearance of chronic pain (incidence between 10-50%) in patients who had undergone routine surgery. On the other hand, few studies have looked at the occurrence of chronic pain in patients who came to the emergency department for acute pain.
It is in this context that the investigators find it relevant to assess the prevalence of moderate to severe chronic pain after an emergency department consultation for severe acute pain.
The physiological mechanisms of pain are better identified and the activation of N-methyl-D-aspartate (NMDA) receptors contributes to the onset of hyperalgesia. These receptors are activated under certain conditions, such as during intense and prolonged pain or exposure to high doses of opioids. In addition, the hyperalgesic effect of opioids is known and widely described in the literature. Finally, in the perioperative period, it is now accepted that the administration of a low dose of ketamine can combat these hyperalgesic effects thanks to its NMDA receptor inhibitory action. This effect may have an impact on pain at six months after surgery.
On the basis of these data, it seems relevant to question the prevalence of chronic pain in the course of an emergency department consultation, all the more so in patients with severe initial pain, in whom there is an initial indication for morphine titration, based on the recommendations of the French Society of Emergency Medicine (SFMU).
In addition, the investigators need to question the effects of initial analgesia administered in the emergency department for patients with severe acute pain. Is there a link between the use of certain molecules or the combination of molecules on the onset of chronic pain?
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: 6 month
The main judgment criteria is the presence of chronic pain, related to the pain that motivated the emergency department visit 6 months earlier, moderate to severe defined as pain evolving since the emergency department visit (6 months), experienced at least 2 times per week, and of intensity ≥ 4 on a numerical pain scale during the patient's last painful experience.
Time frame: 6 month
Compare the prevalence of moderate to severe chronic pain (defined in the primary end point ≥4/10) in the group of patients who initially consulted for pain from traumatic and nontraumatic causes. Traumatic pain is defined as pain related to a traumatic mechanism less than 1 week old.
Time frame: 6 month
Association between the prevalence of chronic pain and pain management in the emergency department at analgesic treatment used per molecule
Time frame: 6 month
Association between the prevalence of chronic pain and pain management in the emergency department at the total dose administered to the emergency department
Time frame: 6 month
Association between the prevalence of chronic pain and pain management in the emergency department in the realization of a locoregional anaesthesia
Time frame: 6 month
Association between the prevalence of chronic pain and pain management in the emergency department in the performance of procedural sedation
Time frame: 6 month
We will assess whether patients with chronic pain at 6 months reconstruct more often than patients without chronic pain by asking them whether or not they consulted a list of medical specialists, paramedics or did other tests.
Time frame: 6 month
Brief Pain Inventory Short Form (BPI-SF) questionnaire, 6 months after their visit to the emergency department.
Time frame: 6 month
The neuropathic characteristics of pain will be characterized by the DN-4 questionnaire
Time frame: 6 month
The SF-12 questionnaire will assess quality of life 6 months after admission to the emergency department
Time frame: 6 month
Analgesic treatment at 6 months will be evaluated by asking the patient his usual analgesic treatment by class of molecule
University Hospital, Grenoble
Other
Prevalence of Chronic Pain After an Emergency Department Visit for Severe Acute Pain and Influence of the Analgesia Initially Used
Acronym: CHROPAIN
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