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NCT Number: NCT07326410

Prevalence of Cerebral Large Vessel Occlusion Among Acute Ischemic Stroke Patients in Assiut University Hospitals

Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals

1. Study Objectives

Primary Objective:

- To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals

Secondary Objectives: * To describe clinical and radiological characteristics of LVO patients. * To assess factors associated with LVO (age, sex, stroke severity, comorbidities). 2. Study Design

* Type: single center, prospective observational cross-sectional study * Duration: 12-month recruitment period * Setting: Assiut university hospitals, stroke unit. 3. Study Population

Inclusion Criteria:

* Adults (≥18 years) * Diagnosed with acute ischemic stroke within 24 hours of symptom onset * Underwent vascular imaging (CTA or MRA) on admission

Exclusion Criteria:

* Hemorrhagic stroke * Stroke mimics * Incomplete imaging data 4. Definitions

Large Vessel Occlusion (LVO) defined as occlusion in:

* Intracranial ICA * M1 or proximal M2 segments of MCA * Basilar artery ± Optional: A1 6. Data Collection

Clinical Data:

* Demographics (age, sex) * Risk factors (HTN, DM, AF, CAD, smoking) * NIHSS on admission and discharge mRS on admission and discharge * Onset-to-door time * Imaging modality used

Imaging Data:

* Site of occlusion * ASPECTS (optional) * Collateral status (optional if available)

Hospital Data:

* Facility type (public vs private) * Door-to-CT and door-to-CTA times 8. Analysis Plan * Primary: Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging * Subgroup analysis: By age group, sex, region, NIHSS * Secondary: Logistic regression to identify predictors of LVO

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Key information

Conditions

Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals

  • Study Objectives

Primary Objective:

  • To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals

Secondary Objectives:

  • To describe clinical and radiological characteristics of LVO patients.
  • To assess factors associated with LVO (age, sex, stroke severity, comorbidities).
  • Study Design
  • Type: single center, prospective observational cross-sectional study
  • Duration: 12-month recruitment period
  • Setting: Assiut university hospitals, stroke unit.
  • Study Population

Inclusion criteria

  • Adults (≥18 years)
  • Diagnosed with acute ischemic stroke within 24 hours of symptom onset
  • Underwent vascular imaging (CTA or MRA) on admission

Exclusion criteria

  • Hemorrhagic stroke
  • Stroke mimics
  • Incomplete imaging data 4. Definitions

Large Vessel Occlusion (LVO) defined as occlusion in:

  • Intracranial ICA
  • M1 or proximal M2 segments of MCA
  • Basilar artery ± Optional: A1 6. Data Collection

Clinical Data:

  • Demographics (age, sex)
  • Risk factors (HTN, DM, AF, CAD, smoking)
  • NIHSS on admission and discharge mRS on admission and discharge
  • Onset-to-door time
  • Imaging modality used

Imaging Data:

  • Site of occlusion
  • ASPECTS (optional)
  • Collateral status (optional if available)

Hospital Data:

  • Facility type (public vs private)
  • Door-to-CT and door-to-CTA times 8. Analysis Plan
  • Primary: Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging
  • Subgroup analysis: By age group, sex, region, NIHSS
  • Secondary: Logistic regression to identify predictors of LVO

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (≥18 years)
  • Diagnosed with acute ischemic stroke within 24 hours of symptom onset
  • Underwent vascular imaging (CTA or MRA) on admission

Exclusion criteria

  • Hemorrhagic stroke
  • Stroke mimics
  • Incomplete imaging data

Treatment and study plan

Primary outcomes

  1. To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals

    Time frame: 12 months

    Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging

Secondary outcomes

  1. -To describe clinical and radiological characteristics of LVO patients. - To assess factors associated with LVO (age, sex, stroke severity, comorbidities).

    Time frame: 12 months

    Subgroup analysis: By age group, sex, region, NIHSS

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Nasr Professor of neurology, Professor

CONTACT

[email protected]

+201009949677

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jan 8, 2026
Registry last updated
Jan 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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