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Enrolling by Invitation

NCT Number: NCT05224583

Prevalence of BK Viremia in Simultaneous Liver-Kidney Transplant

The human BK polyomavirus is a significant risk factor for renal transplant dysfunction and allograft loss. The prevalence of BK viremia (BKV) following kidney transplantation is estimated to be 10-20%.

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Key information

Conditions

Polyomavirus Infections BK Viremia DNA Virus Infections Infections Kidney Transplant Infection Liver Transplant Infection Virus Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Methodist Dallas Medical Center

Dallas, Texas, 75203, United States

About this study

The human BK polyomavirus is a significant risk factor for renal transplant dysfunction and allograft loss. The prevalence of BK viremia (BKV) following kidney transplantation is estimated to be 10-20%. Immunosuppression reduction is the management cornerstone for BKV and has been shown to be effective at clearing the virus while maintaining graft function in both kidney alone and simultaneous kidney-pancreas transplant recipients. However, there is a lack of published data on the prevalence and outcomes in simultaneous liver-kidney (SLK) transplant recipients.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years or older
  • SLK recipients transplanted at MDMC between 2015-2020

Exclusion criteria

  • Below 18 years of age
  • Patients who did not undergo SLK transplant at MDMC

Treatment and study plan

Simultaneous Liver-Kidney Transplant

Procedure

Simultaneous Liver-Kidney Transplant

Primary outcomes

  1. To characterize the prevalence of BKV in the SLK patient population at (Methodist Dallas Medical Center)MDMC.

    Time frame: over a 6-year period (2015 to 2020).

    number of SLK transplant recipients who were transplanted at (Methodist Dallas Medical Center)MDMC

Sponsors and collaborators

Lead sponsor

Methodist Health System

Other

Registry information

Official study title

Prevalence of BK Viremia in Simultaneous Liver-Kidney Transplant Recipients: A Retrospective Single-Center Review

Important dates

Study start
2021
Primary completion
2027
Study completion
2028
First posted
Feb 4, 2022
Registry last updated
Mar 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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