Prevalence of Acute Critical Neurological Disease in Children: a Global Epidemiological Assessment

PANGEA is an international prospective point prevalence study to describe the epidemiology, interventions, and outcomes in children with acute critical brain disease.

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Key information

Conditions

Cardiac Arrest Brain Diseases Brain Injuries Brain Injuries, Traumatic Brain Mass Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Craniocerebral Trauma Heart Arrest Heart Diseases Hydrocephalus Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Seizures Signs and Symptoms Spinal Cord Disease Spinal Cord Diseases Status Epilepticus Stroke Trauma, Nervous System Traumatic Brain Injury Vascular Diseases Wounds and Injuries

Age range

7 day–17 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children aged 7 days to 17 years inclusively and admitted to an ICU (ICU can be classified as general, cardiac, trauma, etc).
Children with acute or acute on chronic neurologic disease that occurred just prior to hospital admission or occurred during the hospital admission.
Acute neurologic disease is secondary to TBI, stroke, brain mass, hydrocephalus, cardiac arrest, status epilepticus, CNS infection/inflammation, or spinal cord injury.

Exclusion criteria

Children with acute perinatal neurologic disease.
Children with isolated chronic brain injury and no acute neurologic disease.

Treatment and study plan

No intervention

Other

Primary outcomes

Prevalence of acute brain insult

Time frame: 4 days over a 1 year period

Secondary outcomes

Mortality

Time frame: Hospital discharge or 3 months

Sponsors and collaborators

Lead sponsor

University of Pittsburgh

Other

Collaborators

Laerdal Medical

Registry information

Acronym: PANGEA

Important dates

Study start: 2011
Primary completion: 2012
Study completion: 2014
First posted: Mar 6, 2015
Registry last updated: Mar 6, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed