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OpenTrials
Completed

NCT Number: NCT05688150

Prevalence and Associated Factors of Sarcopenia Among Elderly Patients in Osteoporosis Clinic

This was a cross-sectional study. Patients who attended the osteoporosis clinic of Kowloon Hospital from June to December 2022 were recruited.

Grip strength and appendicular skeletal muscle mass index were measured with a Jamar dynamometer and a bioimpedance analyser. Since most patients in our clinic are of Chinese ethnicity, the diagnostic criteria in the Consensus Update on Sarcopenia Diagnosis and Treatment by the Asian Working Group for Sarcopenia in 2019 was utilised. The diagnosis of sarcopenia was established by the presence of both low grip strength (Male: < 28 kg, Female < 18 kg) and low appendicular skeletal mass (Male: < 7.0 kg/m2, Female: < 5.7 kg/m2)

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Key information

Conditions

Sarcopenia Atrophy Bone Diseases Bone Diseases, Metabolic Metabolic Diseases Muscular Atrophy Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Nutritional and Metabolic Diseases Osteoporosis Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Kowloon Hospital

Kowloon, Hong Kong

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 60 years old or above
  • Diagnosed with osteoporosis by: Fragility fracture or T-score ≤-2.5 SDs at any site on DXA scan and;
  • Able to read and write Chinese

Exclusion criteria

  • Unable to maintain standing posture for bioimpedance analysis
  • Modified Functional Ambulation Classification (MFAC) ≤ IV
  • Incompetent in giving consent
  • Unable to follow instructions
  • Implanted with metal in any of four limbs
  • Implanted with pacemaker, implantable cardioverter defibrillator or any other types of electrical device

Treatment and study plan

Primary outcomes

  1. Prevalence of Sarcopenia

    Time frame: June - December 2022

    The diagnosis of sarcopenia would be established by the co-existence of low grip strength and low appendicular skeletal muscle mass.

  2. Grip strength

    Time frame: June - December 2022

    Grip strength would be measured with Jamar digital dynamometer.

  3. Appendicular Skeletal Muscle Mass Index

    Time frame: June - December 2022

    Appendicular Skeletal Muscle Mass Index would be measured with bioimpedance analyzer.

Secondary outcomes

  1. Association between BMI and Sarcopenia.

    Time frame: June - December 2022

    BMI would be measured on clinic attendance.

  2. Association between Frailty and Sarcopenia.

    Time frame: June - December 2022

    Clinical Frailty Scale would be documented in clinical consultation.

  3. Association between Charlson Comorbidities Index and Sarcopenia

    Time frame: June - December 2022

    Components of Charlson Comorbidities Index would be extracted from medical record.

  4. Association between Bone Mineral Densities and Sarcopenia

    Time frame: June - December 2022

    Bone mineral densities of spine and neck of femur would be extracted from the report of dual-energy X-ray absorptiometry.

Sponsors and collaborators

Lead sponsor

Kowloon Hospital, Hong Kong

Other

Registry information

Important dates

Study start
2022
Primary completion
2022
Study completion
2023
First posted
Jan 18, 2023
Registry last updated
Feb 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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