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Completed

NCT Number: NCT01155648

Pressure Support During Chest Wall Compression

The purpose of this study is to compare two physiotherapy techniques: chest wall compression versus chest wall compression plus increase of 10 cmH2O in inspiratory pressure.

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Key information

Conditions

Respiration, Artificial Critical Care Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

About this study

  • After being placed in the supine position in bed, with head angle elevation at 30°, patients were randomized to:group 1 (G1): chest wall compression for ten minutes in chest or group 2 (G2): chest wall compression plus increase of 10 cmH2O in IP in PSV for ten minutes in chest.
  • Clinical variables and APACHE II were registered.
  • Parameters analyzed at the beginning (1) and at the end (2) of the protocol were: variation of peak pressure (ΔPp=Pp2-Pp1),variation of tidal volume (ΔVT =VT2-VT1), variation of dynamic compliance (ΔCdyn= Cdyn2-Cdyn1).
  • The amount of variation of mucus secretion aspirated (ΔSa= Sa2-Sa1) at the end was also measured

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients on mechanical ventilation over 48 hours
  • With ventilatory drive
  • Hemodynamically stable MAP> 60 mmHg
  • With treatment of respiratory therapy

Exclusion criteria

  • Contra indication of increased positive inspiratory pressure
  • Peak pressure in the upper airway > 40 cmH2O
  • Osteoporosis diagnosis
  • Deny to participate in the study

Treatment and study plan

Chest wall compression plus increase of 10 cmH2O in inspiratory pressure during Pressure Support Ventilation for ten minutes in chest.

Device

Chest wall compression for ten minutes in chest

Device

Primary outcomes

  1. Variation of mucus secretion aspirated.

    Time frame: Two years

Secondary outcomes

  1. Hemodynamic and pulmonary parameters.

    Time frame: Two years

    The hemodynamic and pulmonary parameters were collected: Hart rate (HH), respiratory rate (f), mean arterial pressure (MAP) and peripheral arterial saturation of oxygen (SpO2); peak inspiratory pressure (Ppeak),and Tidal volume (VT) measured in the ventilator, dynamic compliance (Cdyn calculated through the formula VT/ Ppeak - PEEP)

Sponsors and collaborators

Lead sponsor

Hospital de Clinicas de Porto Alegre

Other

Registry information

Official study title

Increasing Pressure Support During Chest Wall Compression is Useful During Respiratory Therapy?

Important dates

Study start
2008
Primary completion
2009
Study completion
2010
First posted
Jul 2, 2010
Registry last updated
Jul 2, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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