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Completed

NCT Number: NCT05690867

Pressure Controlled Ventilation Versus Volume Controlled Ventilation in Upper Abdominal Surgery

Comparison of mechanical powers produced at volume controlled and pressure controlled mechanical ventilation

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Key information

Conditions

Ventilator Lung

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul University, Department of Anesthesiology

Istanbul, 34093, Turkey (Türkiye)

About this study

The mechanical power created by mechanical ventilation, as a new concept, can enable to evaluate the effect of different components in the lung.Our aim in this study is to calculate mechanical power in different ventilation modes ( pressure controlled and volume controlled ventilation) and to compare them. To calculate the mechanical powers we will use Van der Meijden's mechanical power formula for pressure controlled ventilation and for volume controlled ventilation we will use Gattinoni's mechanical power formula. In the literature we haven't seen any publication comparing the mechanical power of two commonly used ventilation modes (volume controlled and pressure controlled ventilation)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA1-2 , >18 years old patients having upper abdominal surgery

Exclusion criteria

  • chronic obstructive lung disease, interstitial lung disease
  • chronic renal failure
  • Child-Pugh > 6 liver disease
  • Patients who don't give consent
  • NYHA > 2 heart failure

Treatment and study plan

Starting with volume controlled ventilation and changing the ventilation mode every 20 minutes

Other

group 1 starts with volume controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to pressure controlled ventilation after letting washout we take three consecutive measurements at pressure controlled ventilation and we will repeat this protocol during surgery

Starting with pressure controlled ventilation and changing the ventilation mode every 20 minutes

Other

group 2 starts with pressure controlled ventilation and we take three consecutive measurements in twenty minutes , after twenty minutes we change the ventilation mode to volume controlled ventilation after letting washout we take three consecutive measurements at volume controlled ventilation and we will repeat this protocol during surgery

Primary outcomes

  1. calculation of mechanical power changes in two different ventilation modes

    Time frame: change from at the beginning of surgery till the end of surgery

    mechanical power will be calculated using the Van der Meijden's formula for pressure support ventilation and Gattinoni's formula for volume controlled ventilation and two mechanical powers will be compared

Secondary outcomes

  1. postoperative pulmonary complications

    Time frame: post-operative 7 days

    postoperative pulmonary complication including pneumonia, acute lung injury, respiratory failure requiring reintubation

  2. hospitalisation time

    Time frame: up to 20 days

    up to 20 days

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

Comparison of Pressure and Volume Controlled Ventilation in Terms of Mechanical Power in Upper Abdominal Surgery

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jan 19, 2023
Registry last updated
Jan 19, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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