Skip to main content
OpenTrials
Completed

NCT Number: NCT03776370

Preserving Left Colonic Artery During Radical Resection of Rectal Cancer

To evaluate the feasibility and clinical significance of preserving left colonic artery in rectal cancer surgery.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Postoperative Complications Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Proteinosis Rectal Diseases Rectal Neoplasms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

zongming,Kang, Chongqing, Chongqing Municipality, China

Loading trial locations.

About this study

The investigators performed three-dimensional (3D) reconstruction to investigate the vascular anatomy, including the inferior mesenteric artery (IMA) and left colic artery (LCA),to help make pre-operative strategies of rectal cancer surgery.The investigators will preserving the left colonic artery during rectal cancer surgery and evaluate its feasibility and clinical significance.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pathological biopsy confirmed adenocarcinoma of the rectum；
  • Preoperative assessment of tolerance to surgery without major organ dysfunction；
  • Patients must be able to understand and voluntarily sign written informed consent；
  • The surgical method is laparoscopic or robotic anterior rectal cancer resection.

Exclusion criteria

  • The patient cannot tolerate the operation；
  • Refusal to sign informed consent；
  • Patients with distant metastasis of rectal cancer；
  • The surgical method was changed to miles or Hartman;
  • Unable to complete the follow - up

Treatment and study plan

Preserve the left colonic artery

Procedure

Preservation of left colonic artery in rectal cancer surgery.

The left colonic artery is not preserved

Procedure

The left colonic artery was dissected in rectal cancer surgery.

Primary outcomes

  1. The incidence of postoperative anastomotic leakage was compared between the two groups.

    Time frame: Within 30 days after surgery

    The incidence of anastomotic leakage within 30 days after surgery was compared between the intervention group and the control group.

  2. The distant metastasis rates of rectal cancer between the two groups were compared.

    Time frame: Two years after surgery

    The incidence of distant metastasis rectal cancer within two years after surgery was compared between the intervention group and the control group.

  3. The local recurrence rates of rectal cancer between the two groups were compared.

    Time frame: Two years after surgery

    The incidence of local recurrence rectal cancer within two years after surgery was compared between the intervention group and the control group.

  4. The five-year survival rates of rectal cancer between the two groups were compared.

    Time frame: Five years after surgery

    The 5-year survival rates of rectal cancer in the intervention group and the control group were compared.

Sponsors and collaborators

Lead sponsor

Third Military Medical University

Other

Registry information

Official study title

A Clinical Cohort Study on the Effect of Preserving Left Colonic Artery During Radical Resection of Rectal Cancer on Anastomotic Leakage and Oncology Efficacy

Important dates

Study start
2018
Primary completion
2022
Study completion
2022
First posted
Dec 14, 2018
Registry last updated
May 4, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.