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Completed

NCT Number: NCT07322744

Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients

Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear. This study aimed to evaluate the frailty-stratified association between preoperative LMR and POD in older surgical patients.

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Key information

Conditions

Postoperative Delirium (POD) Confusion Delirium Emergence Delirium Frailty Frailty At Older Adults Lymphocyte Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

28 Fuxing Road, Haidian District

Beijing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged ≥65 years;
  • Underwent elective noncardiac, nonneurosurgical procedures;
  • Completed the preoperative health and functional status questionnaire.

Exclusion criteria

  • Severe dementia, language disorders, significant hearing or visual impairments, or coma;
  • Cognitive function below the Mini-Mental State Examination thresholds (<18 for illiterate individuals, <21 for individuals with primary education, and <25 for individuals with secondary education or higher);
  • Surgery performed under local anesthesia or monitored anesthesia care;
  • Missing lymphocyte or monocyte count data;
  • Missing postoperative delirium assessment;
  • Incomplete preoperative FRAIL scale evaluation;
  • Missing data for more than 20% of covariates.

Treatment and study plan

Primary outcomes

  1. The primary outcome was the occurrence of postoperative delirium (POD).

    Time frame: POD assessment was performed twice daily for up to seven consecutive postoperative days or until hospital discharge, whichever occurred first.

    The primary outcome was the occurrence of POD, evaluated by trained researchers using the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM).

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Official study title

Association Between Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium According to Frailty Status in Older Surgical Patients: A Prospective Cohort Study

Important dates

Study start
2020
Primary completion
2022
Study completion
2023
First posted
Jan 7, 2026
Registry last updated
Jan 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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