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Completed

NCT Number: NCT05390281

Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery

Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. This study will investigate the association of preoperative HbA1c levels with AKI after isolated coronary artery bypass grafting (CABG).

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

45 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain-Shams University

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA physical status II-III
  • scheduled to undergo isolated coronary artery bypass grafting

Exclusion criteria

  • Patients with history of renal failure
  • Patients with history of hepatic failure
  • Patients with history of heart failure
  • previous cardiac surgery
  • cerebrovascular event in the last 30 days
  • percutaneous coronary intervention in the last 30 days prior to operation
  • peripheral arterial disease
  • malignancy
  • infectious diseases
  • patients who required surgical revision
  • patients who required postoperative intra-aortic balloon pump
  • patients with CBP time > 120 min or aortic cross clamp time > 90 min

Treatment and study plan

increase in serum creatinine

Diagnostic Test

any of the following: increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinin

Primary outcomes

  1. serum creatinine level

    Time frame: 3 days

    increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinine to ≥ 1.5 times baseline within 3 days of cardiac surgery

Secondary outcomes

  1. Patients in need of RRT

    Time frame: 7 days

    The number of patients requiring postoperative renal replacement therapy

Other outcomes

  1. Length of ICU stay

    Time frame: 7days

    The duration of postoperative patient stay in the intensive care

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Association Between Preoperative Level of Hemoglobin A1c and the Incidence of Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery: a Cohort Study

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
May 25, 2022
Registry last updated
Jan 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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