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NCT Number: NCT07399093

Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index After Induction of General Anesthesia

This study aims to assess the accuracy, repeatability, and reproducibility of preoperative evaluation of Inferior Vena Cava (IVC) collapsibility index and caval aorta index for prediction of hypotension after induction of general anesthesia.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain Shams University Hospitals

Cairo, 11591, Egypt

Location status: Recruiting

Location contact

Dalia A Mohamed, MD

SUB_INVESTIGATOR

Mai M Elhefny, MD

SUB_INVESTIGATOR

Noha M EL-Tobgy, MD

SUB_INVESTIGATOR

Sherif W Sarguios, MD

SUB_INVESTIGATOR

Verina F Bekheet, MSc

CONTACT

[email protected]

00201098858385

About this study

Post- anesthesia hypotension is of common occurrence, and it hampers tissue perfusion. The magnitude of hypotension is determined by the preoperative volume status, which varies depending on American Society of Anesthesiologists (ASA) physical status, preoperative comorbidities, preoperative medications, and fasting.

General anesthesia causes significant alterations in hemodynamics, as both inhalational and intravenous anesthetics cause bradycardia, decrease in systemic vascular resistance and vasodilatation, and decrease in myocardial contractility, cardiac output and stroke volume, with the absence of surgical stimulus, making induction of anesthesia is the most crucial period at which hypotension occurs.

Due to different definitions of hypotension and diverse patient populations, the effect of volume preload on prevention of hypotension is still controversial. Many recommendations to identified sonographic determination of inferior vena cava (IVC) collapsibility index (IVCCI) as non-invasive, and easy technique for evaluating volume status. Recent guidelines from the American Society of Echocardiography support the general use of IVCCI in assessing volume status.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 18 to 40 years.
  • Both sexes.
  • Body Mass Index< 40 kg/m².
  • American Society of Anesthesiologists (ASA) physical status I, II.
  • Fasted according to the ASA guidelines: 2 hours for clear fluids, 6 hours after light meal, 8 hours after a full meal with high calorie or fat content.
  • Scheduled for elective craniotomy surgeries before induction of general anesthesia.

Exclusion criteria

  • Current or recent pregnancy (within 3 months).
  • Pre-existing cardiac disease or hypertension.
  • On medications affecting blood pressure [Beta-blockers (BBs) and calcium channel blockers (CCBs)] .
  • Refusing to undergo the study.

Treatment and study plan

Inferior Vena Cava Collapsibility Index

Other

Inferior vena cava (IVC) collapsibility index (IVCCI) will be measured.

The IVCCI is calculated using the following formula:

IVCCI = (maximum IVC diameter - minimum IVC diameter) / maximum IVC diameter * 100

Caval Aorta Index

Other

The Inferior vena cava (IVC): Ao index will be derived by taking the ratio of the maximum IVC diameter during expiration and the maximal abdominal aortic diameter during systole.

  • The caval aorta index (IVC/Ao) is calculated using the following formula: IVC/Ao index = IVC diameter / aortic diameter.

Primary outcomes

  1. Sensitivity of ultrasound guided Aorto-Caval index (IVC-AO)

    Time frame: 15 minutes post-induction of general anesthesia.

    Sensitivity of ultrasound guided Aorto-Caval index (IVC-AO) to predict hypotension will be recorded.

Secondary outcomes

  1. Specificity of ultrasound guided Aorto-Caval index (IVC-AO)

    Time frame: 15 minutes post-induction of general anesthesia.

    Specificity of ultrasound guided Aorto-Caval index (IVC-AO) to predict hypotension will be recorded.

  2. Sensitivity of inferior vena cava (IVC) collapsibility index

    Time frame: 15 minutes post-induction of general anesthesia.

    Sensitivity of inferior vena cava (IVC) collapsibility index to predict hypotension will be recorded.

  3. Specificity of inferior vena cava (IVC) collapsibility index

    Time frame: 15 minutes post-induction of general anesthesia.

    Specificity of inferior vena cava (IVC) collapsibility index to predict hypotension will be recorded.

Study contacts

Contact information is provided by the study sponsor or research team.

Verina F Zaref, MSc

CONTACT

[email protected]

00201098858385

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index for Prediction of Hypotension After Induction of General Anesthesia in Patients Undergoing Craniotomy Surgeries

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Feb 10, 2026
Registry last updated
Feb 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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