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OpenTrials
Completed

NCT Number: NCT03355911

Preoperative Corneal Thickness and Postoperative Visual Outcomes After Posterior Lamellar Corneal Transplant

To evaluate the impact of preoperative corneal thickness on visual outcomes following Descemet's stripping endothelial keratoplasty (DSAEK) or Descemet membrane endothelial keratoplasty (DMEK)

Completed

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Key information

Conditions

Corneal Changes of Membranes

Study type

Observational

About this study

Patients underwent DSAEK or DMEK for endothelial dysfunction, from October 2013 to November 2016. Patients aged > 18 years and with an indication for posterior lamellar graft surgery, such as Fuchs dystrophy, were included. Exclusion criteria included a history of penetrating keratoplasty in the study eye and a need for a penetrating keratoplasty following endothelial graft failure. Visual acuity, central corneal thickness (CCT) and graft thickness were measured preoperatively, and at postoperative day 7 and months 1, 3 and 6.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinically indicated need for posterior lamellar graft surgery (DSAEK or DMEK) such as:
  • Fuchs dystrophy,
  • pseudophakic bullous decompensation
  • or other endothelial dysfunction corneal

Exclusion criteria

  • were a history of penetrating keratoplasty in the indicated eye
  • the technical inability of preoperative CCT measurement
  • the need for a penetrating keratoplasty following endothelial graft failure
  • severe postoperative complications resulting in unquantifiable visual acuity

Treatment and study plan

Primary outcomes

  1. Descemet's stripping endothelial keratoplasty (DSAEK) or Descemet membrane endothelial keratoplasty (DMEK)

    Time frame: month 6

    LogMar

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Régional Metz-Thionville

Other

Registry information

Official study title

Relationship Between Preoperative Corneal Thickness and Postoperative

Acronym: TransCor

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Nov 28, 2017
Registry last updated
Dec 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.