Prenatal Exposure Effects Psychophysiology Study

The investigators are looking for pregnant women or mothers with their newborn infants to participate in this study. Eligible women include mothers who have used any of the following drugs at any time during pregnancy (alone or in combination):

• cocaine
• nicotine (cigarettes)
• marijuana
• alcohol

The investigators are also looking for mothers who have not used any drugs during pregnancy.

Information collected in this research study is strictly confidential, and protection of sensitive information is additionally assured by an NIH Certificate of Confidentiality.

Participation in this study involves:

• One visit at 2-4 weeks postpartum. This visit includes an interview for mother and a 30 minute brain scan (no radiation, no sedation) for baby.
• Two visits at 3 months postpartum. Mothers will have blood pressure and heart rate measured while they look at videos about babies, listen to baby sounds, interact with their own baby. Samples of blood, urine and saliva will be taken from mother. Baby will have a developmental assessment, and saliva samples will be taken.

Payment is $300 or the equivalent in Walmart gift cards for completion of brain imaging, lab visits and 1 day of monitoring mother's blood pressure at home.

Inclusion criteria

• During pregnancy, mother has used any of the following:

• cocaine
• marijuana and/or alcohol but not cocaine
• nicotine (smoked cigarettes)
• no drugs during pregnancy
• Mother is pregnant or no more than 4 weeks postpartum

Exclusion criteria

• Mother has cardiovascular disease
• Delivery before 36 weeks or later than 42 weeks gestation
• Birth weight less than 5.5 lbs
• Baby was a multiple birth