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Completed

NCT Number: NCT03362450

Prenatal Diagnosis of Antenatal Midgut Volvulus: Specific Ultrasound Features

Objective:

The small bowel volvulus is a rare cause of intestinal obstruction which may occur in utero and whose prenatal diagnosis is difficult.Sonographic signs are mainly indirect and non specific.The aim of this study is to present a retrospective analysis of prenatal sonographicfindings in fetal segmental midgut volvulus.Thanks to this series the investigators could highlight the more specifics signs of the volvulus included a new pattern.

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Key information

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Uhmontpellier

Montpellier, 34295, France

About this study

Objective:

The small bowel volvulus is a rare cause of intestinal obstruction which may occur in utero and whose prenatal diagnosis is difficult. Sonographic signs are mainly indirect and nonspecific. The aim of this study is to present a retrospective analysis of prenatal sonographic findings in fetal segmental midgut volvulus. Thanks to this series the investigators could highlight the more specifics signs of the volvulus included a new pattern.

Methods:

Unicentric retrospective analysis of cases of prenatal midgut volvulus between 2006 and 2017. The primary inclusion criteria was postnatal diagnosis of prenatal volvulus based on post-natal findings and prenatal imaging findings. The exclusion criteria was the absence of prenatal imaging assessment. The investigators collected the clinical history and the echographic mode B and color Doppler. They have searched for some specific sign like " whirlpool sign " representing the winding of the mesenteric vein around the superior mesenteric arterywith color Doppler with arciform pattern of the midgut, hydro-meconium level in the dilated loops and position of mesenteric vessels for evaluation of the intestinal (mal) rotation. Gold standard was surgery or foetopathology if performed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • postnatal diagnosis of prenatal volvulus based on post-natal findings and prenatal imaging findings

Exclusion criteria

  • the absence of prenatal imaging assessment

Treatment and study plan

Fetal ultrasound during the second or third trimester/ Postnatal surgery / Post mortem examination

Other

Fetal ultrasound during the second or third trimester Postnatal surgery Post mortem examination

Primary outcomes

  1. echography

    Time frame: during the second (22-24 weeks) after ultrasound screening

    Observation of specific signs using echography for the diagnosis of fetal during the second (22-24 weeks) and the third (31-34 weeks) trimester after ultrasound screening and when diagnostic ultrasound were performedmidgut volvulus

  2. echography

    Time frame: the third (31-34 weeks) trimester after ultrasound screening

    Observation of specific signs using echography for the diagnosis of fetal

Secondary outcomes

  1. ultrasound signs of complication

    Time frame: the third (31-34 weeks) after ultrasound screening

    Observation of ultrasound signs of complication of midgut volvulus during the pregnancy like meconial pseudocyst, ascites, meconial peritonitis.

  2. ultrasound signs of complication

    Time frame: during the second (22-24 weeks) after ultrasound screening

    Observation of ultrasound signs of complication of midgut volvulus during the pregnancy like meconial pseudocyst, ascites, meconial peritonitis.

  3. ultrasound signs of complication

    Time frame: 1 day

    Observation of ultrasound signs of complication of midgut volvulus during the pregnancy like meconial pseudocyst, ascites, meconial peritonitis after diagnostic ultrasound.

  4. ultrasound signs of complication

    Time frame: just after delivery

    Observation of ultrasound signs of complication of midgut volvulus during the pregnancy like meconial pseudocyst, ascites, meconial peritonitis.

  5. presence or not of the volvulus

    Time frame: 1 day

    Observation of surgery outcome like presence or not of the volvulus after diagnostic ultrasound

  6. presence or not of the volvulus

    Time frame: during the second (22-24 weeks) after ultrasound screening

    Observation of surgery outcome like presence or not of the volvulus

  7. presence or not of the volvulus

    Time frame: just after delivery

    Observation of surgery outcome like presence or not of the volvulus

  8. presence or not of the volvulus

    Time frame: the third (31-34 weeks) after ultrasound screening

    Observation of surgery outcome like presence or not of the volvulus

  9. presence or not ileal atresia.

    Time frame: during the second (22-24 weeks) after ultrasound screening

    Observation of surgery outcome like presence or not ileal atresia

  10. presence or not ileal atresia.

    Time frame: the third (31-34 weeks) after ultrasound screening

    Observation of surgery outcome like presence or not ileal atresia

  11. presence or not ileal atresia.

    Time frame: just after delivery

    Observation of surgery outcome like presence or not ileal atresia

  12. presence or not ileal atresia.

    Time frame: 1 day

    Observation of surgery outcome like presence or not ileal atresia after diagnostic ultrasound

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Important dates

Study start
2006
Primary completion
2017
Study completion
2017
First posted
Dec 5, 2017
Registry last updated
Dec 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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