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OpenTrials
Completed

NCT Number: NCT02740907

Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth

Objective:

Premolar autotransplantation represents an effective therapeutic option for the treatment of juvenile dentition in traumatic dental injury with tooth loss. Numerous studies report on the osteoinductive potency of the method, however, to date no quantitative data has been provided. The objective of this prospective clinical study was to quantitatively assess the bone and soft tissue levels after autogenous premolar transplantation by clinical and radiographic parameters.

Materials/Methods:

In the study 26 premolars were transplanted in 20 patients after traumatic dental injury (n=10) or tooth aplasia (n=16) in the upper front. Standard clinical parameters were evaluated. Based on a standardized photo documentation, the relative soft tissue level was measured in comparison to the healthy adjacent teeth. Radiographic findings involved the evaluation of root resorption, pulp canal obliterations and the relative bone height. Patient satisfaction was determined using a standardized questionnaire.

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Key information

Age range

10 year–17 year

Sex eligibility

All sexes

Study type

Observational

Primary location

MKG Praxisklinik

Munich, Sauerbruchstraße 48, 81377, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • premolar transplantation after tooth loss in the anterior maxilla (13-23) by aplasia or trauma

Treatment and study plan

premolar autotransplantation

Procedure

Autogenous tooth transplantation of premolars to the anterior maxilla to stimulate bone and soft tissue growth.

Primary outcomes

  1. Transplant survival

    Time frame: 2006-2014

    Evaluation by Kaplan-Meier-Estimator.

  2. Soft tissue development

    Time frame: 2006-2014

    Measurement by standardized clinical documentation.

  3. Bone development

    Time frame: 2006-2014

    Measurement by radiographic evaluation.

  4. Sensibility

    Time frame: 2006-2014

    Assessment of clinical sensibility.

  5. Root resorptions

    Time frame: 2006-2014

    Radiographic evaluation.

  6. Pulp obliteration

    Time frame: 2006-2014

    Radiographic evaluation.

Sponsors and collaborators

Lead sponsor

MKG-Praxisklinik

Other

Registry information

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Apr 15, 2016
Registry last updated
Apr 15, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.