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OpenTrials
Completed

NCT Number: NCT00780858

Premature Luteinization Prevention by GnRH Antagonist in Patients Undergoing IUI

Premature luteinization in patients undergoing IUI can occur in up to 24% of cycles. These patients, according to recent data, have a lower pregnancy rate than controls. The possibility to avoid premature luteinization with GnRH antagonist may restore the chances of achieving a pregnancy in these women.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

IVI-Madrid

Madrid, 28023, Spain

About this study

The purpose of this study was to investigate whether a subset of patients benefits from GnRHa administration during IUI. PL was tested for in patients who were undergoing artificial insemination procedures, and the effect of GnRHa on PR in patients who

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • previous failed IUI cycle with premature luteinization

Exclusion criteria

  • 39 years or older
  • not eligible for IUI (patent tubes, > 3 million capacitated spermatozoa)
  • 4 previous IUI cycles

Treatment and study plan

Ganirelix

Drug

Ganirelix 0.25mg s.c every 24 h starting stimulation day 6

Other names: Orgalutran

Primary outcomes

  1. Pregnancy rate

    Time frame: 2 weeks after intervention

Secondary outcomes

  1. premature luteinization

    Time frame: at the time of intervention

Sponsors and collaborators

Lead sponsor

IVI Madrid

Other

Registry information

Official study title

GnRH Antagonist Prevention of Premature Luteinization in Patients Undergoing IUI

Acronym: LP

Important dates

Study start
2008
Primary completion
2010
Study completion
2011
First posted
Oct 28, 2008
Registry last updated
May 6, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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