Pregnancy Rate by HCG Administration Versus Urinary LH Surge Method in Patients Undergoing IUI

To compare pregnancy rate by Human Chorionic Gonadotropin (HCG) administration and urinary Luteinizing Hormone (LH) surge method for insemination in patients undergoing Intrauterine Insemination (IUI) at Montaserieh infertility center.

The present study comprised 309 infertile women candidate for IUI, randomly divided into LH surge and HCG groups (assign the number for each patient, odds number for LH and even number for HCG group). All patients were subjected to baseline ultrasound and received clomiphene citrate before undergoing serial transvaginal sonography. LH was measured using LH kit when 2-5 follicles (18-20 mm) appeared in LH surge group, and if positive, IUI was performed after 24 hours. In HCG group, the patients received HCG 1000 units and underwent IUI after 36 hours. The pregnancy rate was then compared in LH and HCG groups.

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Key information

Conditions

Pregnancy

Study type

Interventional

Phase

Phase 4

Primary location

Health Policy Research Center

Shiraz, Fars, Iran

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

infertile women candidate for IUI

Exclusion criteria

women with negative urinary LH surge which required HCG administration,
those with more than 5 follicles who had to use LH kit and not receive HCG to avoid ovarian hyperstimulation.

Treatment and study plan

LH

Drug

HCG

Drug

Clomiphene

Drug

Primary outcomes

pregnancy rate

Time frame: Two weeks after IUI

Sponsors and collaborators

Lead sponsor

Shiraz University of Medical Sciences

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2009
First posted: Dec 23, 2015
Registry last updated: Dec 23, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed