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OpenTrials
Completed

NCT Number: NCT03315806

Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation

Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus. Beetroot juice (BJ) promotes improvement ins this parameters in no-pregnant individuals, however the beneficial effect did not avaliated in pregnant. The present study evaluated effects of BJ on macro and microvascular endothelial function in pregnant. Twelve pregnant were submitted to BJ and nitrate-depleted juice (PLA) interventions. Brachial flow-mediated dilation (FMD) and muscle oxygenation were measured 120 min after interventions. Urinary nitrate, nitrite were measured at baseline and 120 min after interventions.

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Key information

Conditions

Pregnancy

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • gestation between 20 and 35 weeks;
  • over 18 years

Exclusion criteria

  • diabetes mellitus and gestational diabetes;
  • hypertensive syndromes;
  • HIV positive;
  • liver or kidney disease;
  • beetroot allergy;
  • use of antioxidants and medicament that alter endothelial function;
  • use of antibiotics up to 2 weeks before the visits and using.

Treatment and study plan

Beetroot Juice

Other

140 mL of beetroot juice cointaning approximately 9 mmol of nitrate

Placebo

Other

140 mL of beetroot juice isent of nitrate

Primary outcomes

  1. Macro endothelial function

    Time frame: Evaluated 120 minutes after the nutritional intervention

    Flow-mediated dilation (FMD)

  2. Micro endothelial function

    Time frame: Evaluated 140 minutes after the nutritional intervention

    Tissue oxygen saturation parameters

  3. Nitrate urinary

    Time frame: Evaluated 150 minutes after the nutritional intervention

Sponsors and collaborators

Lead sponsor

Universidade Federal do Rio de Janeiro

Other

Registry information

Official study title

Effect of Beetroot Juice Consumption on Endothelial Function and Tissue Oxygen Saturation in Pregnant

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Oct 20, 2017
Registry last updated
Dec 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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