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NCT Number: NCT07377188

Pregnancy and Inflammatory Bowel Disease

Inflammatory Bowel disease, including Crohn's disease and Ulcerative Colitis, are chronic diseases.

Diagnosis is most often done in women of childbearing age. IBD can have and increase the risk of intrauterine growth retardation, preterm birth… Conversely, pregnancy can have an impact on IBD activity during pregnancy. Moreover, IBD course can be influence in post-partum. The investigators will explore IBD course on 945 patients from the EPIMAD register. The investigators will cross the data on the IBD with data on pregnancy, postpartum but also breastfeeding. The principal aim of this study is to assess the number of flares during pregnancy.

Recruiting

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Key information

Conditions

IBD Colitis Colitis, Ulcerative Colonic Diseases Crohn Disease Crohn's Disease Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Inflammatory Bowel Diseases Intestinal Diseases Pregnancy Ulcerative Colitis

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women between 18 and 50 years old
  • MICI diagnosed between 1988 and 2018
  • included in EPIMAD registry
  • living in Somme
  • having had at least one pregnancy

Exclusion criteria

  • women who has not had pregnancy
  • not included in EPIMAD register

Treatment and study plan

Primary outcomes

  1. number of IBD flare during pregnancy

    Time frame: 2 years

Secondary outcomes

  1. Number of flare during post-partum period

    Time frame: 2 years

  2. Number of pregnancy

    Time frame: 2 years

  3. number of children

    Time frame: 2 years

  4. Number of Intestinal resection

    Time frame: 2 years

    Intestinal resection due to mici during pregnancy and post-partum

  5. Number of hospitalization

    Time frame: 2 years

    Intestinal resection and hospitalization due to mici during pregnancy and post-partum

  6. Number of miscarriage

    Time frame: 2 years

  7. Number of ectopic pregnancy

    Time frame: 2 years

  8. Time before conception

    Time frame: 2 years

  9. Number of women with exposition to corticosteroid

    Time frame: 2 years

    Exposition to corticosteroid during pregnancy and post-partum

  10. Exposition to biotherapy

    Time frame: 2 years

    Exposition to biotherapy during pregnancy and post-partum

  11. Number and indication of cesarean section

    Time frame: 2 years

  12. Number of anoperineal lesions after the birth

    Time frame: 2 years

  13. Wexner score for continence

    Time frame: 2 years

Study contacts

Contact information is provided by the study sponsor or research team.

Arthur FOULON, Pr

CONTACT

[email protected]

33+3 22 08 73 82

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: MICI-Birth

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Jan 29, 2026
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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