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OpenTrials
Completed

NCT Number: NCT02120703

Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery

Pregabalin is claimed to have superior analgesic effect at lower doses and better pharmacological profile as compared to gabapentin esp. in perioperative pain control after major surgeries like intervertebral disc surgery.

The investigators found that pregabalin is equivalent to gabapentin for relief of post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.

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Key information

Conditions

Intervertebral Disc Prolapse Bone Diseases Hernia Intervertebral Disc Displacement Musculoskeletal Diseases Neurologic Manifestations Pain Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms Spinal Diseases

Age range

30 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

The Aga Khan University Hospital

Karachi, Sindh, 75300, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 30-60 years age
  • Any gender
  • elective micro discectomy for intervertebral disc prolapse

Exclusion criteria

  • micro discectomy at two or more vertebral levels,
  • Instrumentation i.e. pedicle screw fixation, hooks etc.,
  • history of steroids or alcohol use,
  • Multiple co-morbids i.e. renal failure, chronic liver disease,
  • use of anticonvulsant drugs,
  • Spinal deformity,
  • Obesity (BMI >30), 8) inability to understand and respond VAS and
  • patients with known allergy to GABA analogues.

Treatment and study plan

Pregabalin

Drug

Pregablin 75 mg per oral two times a day

Gabapentin

Drug

Gabapentin 200 mg twice daily per oral

Primary outcomes

  1. Pain

    Time frame: 7 days

    Pain measurement using Visual Analogue Score at 24 hours and 7th day of surgery

Sponsors and collaborators

Lead sponsor

Aga Khan University

Other

Registry information

Official study title

Gabapentin vs. Pregabalin for Post Operative Pain in Lumbar Microdiscectomy: a Randomized Controlled Trial.

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
Apr 23, 2014
Registry last updated
Apr 23, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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