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Completed

NCT Number: NCT07433829

Prefrontal Neuroplasticity and Coping Strategies in Healthy Population

The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS) induces immediate changes in prefrontal excitability in healthy individuals, compared to sham stimulation. In this randomized, sham-controlled trial, investigators will assess several psychological measures-including the Perceived Stress Scale and the Coping Inventory for Stressful Situations-to explore how stress levels and coping strategies relate to immediate prefrontal cortex (PFC) activity changes following TBS.

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Key information

Conditions

Health Adult Subjects

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Hong Kong Polytechnic University

Hong Kong, 九龙, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-60 years old;

Exclusion criteria

  • a family history of psychiatric disorders;
  • history of or currently diagnosed neuropsychiatric conditions;
  • history of or active systemic illnesses such as cancer, epilepsy, diabetes, hypertension, or other medical conditions;
  • contraindications to transcranial magnetic stimulation (TMS);
  • any prior exposure to brain stimulation procedures.

Treatment and study plan

Transcranial Magnetic Stimulation

Device

sham stimulation protocols is to mimic the sensations experienced by participants during active stimulation, without stimulating the brain

Other names: Transcranial Magnetic Stimulation Sham

Primary outcomes

  1. iTBS induced prefrontal cortex activity and connectivity

    Time frame: 3 minutes before, during, and after the stimulation

Secondary outcomes

  1. perceived stress scale

    Time frame: the same day before conducting the experiment

  2. coping inventory for stressful situations

    Time frame: the same day before conducting the experiment

Sponsors and collaborators

Lead sponsor

The Hong Kong Polytechnic University

Other

Registry information

Official study title

Prefrontal Neuroplasticity and Coping Strategies in Healthy Population: a Randomized Sham Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 25, 2026
Registry last updated
Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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