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Completed

NCT Number: NCT01989351

Predisposition to Persistent Pain After Orthopaedic Surgery: Genetic Aspects

The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS>4 patients and to compare it to those with VAS<4.

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Key information

Conditions

Chronic Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Istituto Ortopedico G. Pini

Milan, Milano, 20122, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age > 18
  • ASA I to III

Exclusion criteria

  • Contraindications to regional anesthesia procedures
  • Not stabilized neurological diseases
  • Diabetes

Treatment and study plan

Primary outcomes

  1. Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.

    Time frame: 4 months after surgery

Secondary outcomes

  1. Expression frequency of OPRM1, COMT, IL1Ra

    Time frame: 6, 12, 24, 48 hours

  2. Serum concentration of TNFα, TGFβ, IFNγ, IL-6 and IL-10 obtained with ELISA system

    Time frame: 6, 12, 24 and 48 hours postoperatively

Sponsors and collaborators

Lead sponsor

ASST Gaetano Pini-CTO

Other

Registry information

Official study title

LA PREDISPOSIZIONE AL DOLORE PERSISTENTE POST OPERATORIO IN AMBITO ORTOPEDICO: ASPETTI GENETICI

Important dates

Study start
2013
Primary completion
2017
Study completion
2017
First posted
Nov 21, 2013
Registry last updated
Feb 7, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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