Predictors of the Metabolic Effect of Sleep Loss

To test whether baseline levels of slow wave activity (SWA) during sleep are lower in obese adults, and even lower in persons with sleep disordered breathing (SDB) compared to lean adults.

To compare levels of SWA in individuals in relation to their sleep time, blood pressure, heart rate, and markers of glucose metabolism.

Completed

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Key information

Conditions

Apnea Body Weight Dyssomnias Nervous System Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obstructive Sleep Apnea (OSA) Overnutrition Overweight Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

25 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Chicago

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy,
normal sleepers,
lean, overweight,
obese,
pre menopausal

Exclusion criteria

no shift workers or night-shift workers,
no mental health disorders,
no acute or chronic health conditions (stable, well controlled hypertension are accepted),
no hormonal treatments,
no substances that may interfere with sleep,
problems with sleep

Treatment and study plan

Restriction

Other

Time in bed for each subject is restricted by two hours per night for 4 nights

Extension

Other

Bedtime is extended by 2 hours per night for 4 nights

Primary outcomes

Correlation between SWA, sleep duration,sleep architecture, and biomarkers of the metabolic syndrome in lean, obese with and without obstructive sleep apnea.

Time frame: study completion

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Acronym: SDBO

Important dates

Study start: 2007
Primary completion: 2009
Study completion: 2009
First posted: Aug 26, 2009
Registry last updated: Sep 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed