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Recruiting

NCT Number: NCT05793333

Predictors of Node Positivity in Endometrial Cancer

To investigate the role of histological and moleculr profile of endometrial cancer patietns in predicting the risk of nodal metastases in endometrila cancer patients.

Recruiting

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Key information

Conditions

Endometrial Cancer Endometrial Neoplasms Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Neoplasms Neoplasms by Site Urogenital Diseases Urogenital Neoplasms Uterine Diseases Uterine Neoplasms

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Written informed consent
  • Histologically confirmed endometrila cancer
  • Data on molecular genomic profiling (POLE mutated, p53 abnormalities, MMRd/MSI-H, and NSMP)
  • Data on histological characteristics of the ttumor
  • Execution of sentinel node mapping
  • Data on sentinel node status (negative vs. positive)

Exclusion criteria

  • Stage IVB endoemtrial cancer
  • consent withdraw

Treatment and study plan

Primary outcomes

  1. positive nodes

    Time frame: 12 months

    positive nodes detected by sentinel node mappinig

Study contacts

Contact information is provided by the study sponsor or research team.

Grazia M Casadei, ph.d.

CONTACT

[email protected]

917-275-6975

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Other

Registry information

Official study title

Histological and Molecular Characteristics Predict the Risk of Nodal Involvement in Endometrial Cancer: a Prospective Study

Important dates

Study start
2022
Primary completion
2024
Study completion
2025
First posted
Mar 31, 2023
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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