Predictors of Early Chest Infection in Acute Ischemic Stroke

Pneumonia is a frequent complication of acute stroke and is associated with increased mortality and long-term impairment in the affected subjects. In previous studies, a number of clinical (e.g., dysphagia, severe neurological impairment, mechanical ventilation), radiological (e.g., large infarctions in the territory of middle cerebral artery, insular infarction) and biochemical (e.g., increased serum levels of C-reactive protein, decreased levels of CD4+ T-lymphocytes) findings have been reported as risk factors of stroke-related chest infection. The present study (PRECAST) aims to identify a small set out of these previously described risk factors that can predict stroke-related pneumonia with high sensitivity and specificity.

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Key information

Conditions

Acute Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Deglutition Disorders Digestive System Diseases Esophageal Diseases Gastrointestinal Diseases Infections Ischemic Stroke Lung Diseases Nervous System Diseases Otorhinolaryngologic Diseases Pharyngeal Diseases Pneumonia Respiratory Tract Diseases Respiratory Tract Infections Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Rostock, Department of Neurology

Rostock, D-18147, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

acute ischemic stroke
admission to the neurological intensive care unit or stroke unit within 24 hours after stroke onset
clearly assessed brain lesion location

Exclusion criteria

previous large (non-lacunar) stroke
chest infection present already on hospital admission
mechanical ventilation already on day 1 or 2 after hospital admission
treatment with immunosuppressive drugs

Treatment and study plan

Primary outcomes

diagnosis of chest infection within 7 days after stroke

Time frame: days 1-7 after stroke

Sponsors and collaborators

Lead sponsor

University of Rostock

Other

Registry information

Acronym: PRECAST

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: May 21, 2009
Registry last updated: Feb 19, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed