Predictors of Anticoagulation Control on Warfarin Therapy

The goal of this research study is to develop better dosing of anticoagulation medication in both Caucasian and African Americans through analysis of various genetic factors.

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Key information

Conditions

Atrial Fibrillation Arrhythmias, Cardiac Cardiovascular Diseases Deep Vein Thrombosis Embolism and Thrombosis Heart Diseases Heart Valve Replacement Pathologic Processes Pathological Conditions, Signs and Symptoms Thrombosis Vascular Diseases Venous Thrombosis

Age range

21 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital of the University of Pennsylvania, Anticoagulation Management Center, Philadelphia, Pennsylvania, United States

About this study

This is a prospective cohort study among adult patients requiring warfarin therapy. Patients presenting for anticoagulation will be identified at the start of therapy and followed throughout their course until they reach maintenance dose. We will then develop a dosing equation for warfarin using patient, environmental and genetic factors.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All Caucasians and African Americans who are new to warfarin therapy

Exclusion criteria

Under 21 years of age
Non caucasian
Non african american
Have an abnormal INR before warfarin or heparin therapy
Unable to provide consent

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Important dates

Study start: 2009
Primary completion: 2013
Study completion: 2013
First posted: May 20, 2009
Registry last updated: May 20, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed