Medical University of South Carolina
Charleston, South Carolina, 29425, United States
Location contact
Carla Kmett Danielson, Ph.D.
CONTACT
Rachel Siciliano, Ph.D.
CONTACT
Rachel Siciliano, Ph.D.
PRINCIPAL_INVESTIGATOR
NCT Number: NCT07537764
This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to potential threats, regulating emotions, and repeatedly imagining details of a personally experienced stressful or traumatic event using a script-driven imagery task.
The study evaluates whether repeated imaginal exposure is associated with changes in anxiety and physiological responses across sessions, and whether baseline patterns of threat reactivity and emotion regulation are associated with individual differences in response to the exposure task. Outcomes include self-reported anxiety, subjective distress ratings, and psychophysiological indices such as heart rate, skin conductance, and electromyographic activity.
The goal of this research is to improve understanding of biobehavioral processes related to trauma exposure in adolescents and to identify potential predictors of response to exposure-based intervention components relevant to posttraumatic stress disorder (PTSD).
Trial opening soon.
Get Notified14 year–18 year
All sexes
Interventional
Early Phase 1
Charleston, South Carolina, 29425, United States
Carla Kmett Danielson, Ph.D.
CONTACT
Rachel Siciliano, Ph.D.
CONTACT
Rachel Siciliano, Ph.D.
PRINCIPAL_INVESTIGATOR
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Adolescent Inclusion Criteria:
Adolescent Exclusion Criteria:
Caregiver Inclusion Criteria:
Caregiver Exclusion Criteria:
Repeated administration (5 repetitions) of a script including details of the individual's exposure to a traumatic event.
Time frame: Baseline (Visit 1, prior to first script-driven imagery task) and 1 week after baseline (Visit 2, following repeated imaginal exposure)
Time frame: During script-driven imagery tasks at baseline (Visit 1) and 1 week after baseline (Visit 2)
Time frame: During script-driven imagery tasks at baseline (Visit 1) and 1 week after baseline (Visit 2)
Time frame: During script-driven imagery tasks at baseline (Visit 1) and 1 week after baseline (Visit 2)
Time frame: Baseline (Visit 1) and 1 month after baseline (Visit 3)
Time frame: Visit 1 (baseline) to Visit 2 (1 week)
Contact information is provided by the study sponsor or research team.
Carla Kmett Danielson, Ph.D.
CONTACT
Rachel Siciliano, Ph.D.
CONTACT
Medical University of South Carolina
Other
Identifying Biobehavioral Predictors and Targeting Mechanisms of Intervention in Adolescent Posttraumatic Stress Disorder
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT07718984
Fibromyalgia, Fibromyalgia (FM)
Decatur, Georgia, United States
View Trial DetailsNCT07227987
Brain Diseases, Brain Injuries
Durham, North Carolina, United States
View Trial DetailsNCT07576387
Borderline Personality Disorder, Borderline Personality Disorder (BPD)
Hamilton, Ontario, Canada
View Trial DetailsNCT07526285
Mental Disorders, Posttraumatic Stress Disorder (PTSD)
Charlestown, Massachusetts, United States
View Trial Details