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Completed

NCT Number: NCT06344299

Predictors for Low Rates of Surgical Resection in Elderly Patients With Resectable Pancreatic Ductal Adenocarcinoma

More and more older adults are diagnosed with pancreatic ductal adenocarcinoma (PDAC), but the rate of surgical resection in patients with resectable tumour is still low. Clinical workers need to take more attention to oncologic care in this group. It's significant to explore potential predictors for impacting elderly patients chose to abandon surgical resection.

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Key information

Conditions

Pancreatic Ductal Adenocarcinoma

Age range

75 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Huadong Hospital affiliated to Fudan University

Shanghai, 200040, China

About this study

The incidence of pancreatic ductal adenocarcinoma (PDAC) in the elderly has been on the rise, but the elderly were always neglected in clinical oncology care. Pancreatic ductal adenocarcinoma is a lethal disease, and the most effective treatment for curing it remains the radical resection. Unfortunately, there are many a study had reported that the rate of radical surgery of patients with PDAC has been low in the past decade. In order for more elderly pancreatic cancer patients to undergo surgical resection, investigators extracted the data of elderly patients with PDAC from SEER program and investigated predictive factors associated with surgical resection abandonment. In this study, investigators extracted data of patients older than 75 years diagnosed with T1-T3 stage PDAC to investigate rate of radical surgery. And researchers used Univariate and multivariate logistic regression model to explore potential factors associated with patients and surgeon chose to abandon surgical resection.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients older than 75 years old and were diagnosed with pancreatic ductal adenocarcinoma by positive histology.
  • Patients were diagnosed with T1 through T3, M0 tumor based on criteria of TNM stage.

Exclusion criteria

  • Patients were diagnosed by death certificate.
  • Patients died before radical surgery.
  • Patients with important data missing, such as T-stage, surgical resection status, surgery procedures and complete survival time.

Treatment and study plan

potential predictors

Other

Researchers want to investigate some important factors that influence elderly patients not to undergo radical surgery.

Primary outcomes

  1. ORs of potential predictors

    Time frame: months from diagnosis to surgical resection, up to 12 months

    Univariate and multivariate logistic regression model were used to calculate ORs

Secondary outcomes

  1. Overall survival (OS)

    Time frame: up to 132 months

    The date of definite diagnosis to death or last follow up

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Official study title

Department of Hepato-Biliary-Pancreatic Surgery, Huadong Hospital Affliated to Fudan University

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Apr 3, 2024
Registry last updated
Apr 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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