Predictive Value of β2-microspheres for Postoperative Delirium

This study evaluated the predictive value of β2-microspheres for postoperative delirium (POD) in the elderly after orthopedic surgery. For this purpose, the levels of β2-microspheres in plasma and cerebrospinal fluid were compared between the POD and non-POD groups.

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Key information

Conditions

Postoperative Delirium Confusion Delirium Emergence Delirium Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zhongda Hospital

Nanjing, Jiangsu, 210009, China

About this study

In this study, plasma and cerebrospinal fluid of the patients were collected to detect the levels of β2-microspheres before operation. Also, the patients were interviewed one day before the surgery and on postoperative days 1-3 by the Confusion Assessment Method and then divided them into POD and non-POD groups. The aim of the present study was to assess whether higher levels of β2-microspheres could predict the occurrence of POD.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

≥65 years old, American Standards AssociationⅠ-Ⅲ, undergoing orthopedic operations under spinal anesthesia

Exclusion criteria

decline to participate

Treatment and study plan

Primary outcomes

The incidence of POD

Time frame: 4 days

The patients were interviewed one day before the surgery and on postoperative days 1-3 by the Confusion Assessment Method and then divided them into POD and non-POD groups.

Secondary outcomes

The levels of β2-microspheres in plasma and cerebrospinal fluid

Time frame: 1 day

Before surgery, plasma and cerebrospinal fluid of the patients were collected to detect the levels of β2-microspheres.

Sponsors and collaborators

Lead sponsor

Zhongda Hospital

Other

Registry information

Official study title

The Predictive Value of β2-microspheres for Postoperative Delirium in the Elderly After Orthopedic Surgery

Important dates

Study start: 2015
Primary completion: 2017
Study completion: 2017
First posted: Apr 26, 2017
Registry last updated: Dec 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed