Predictive Value of Right Atrial Strain in Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

The incidence of postoperative atrial fibrillation (POAF) after cardiac surgery is around 30%. POAF increases the risk of developing permanent atrial fibrillation and raises the risk of cardiac decompensation, stroke, acute myocardial infarction, and death. While the role of the left atrium (LAF) in the pathophysiology of POAF is now well-established, the part of the right atrium (RA) remains poorly understood. Recent studies suggest a correlation between RA function and POAF.

RA function can be assessed by transthoracic echocardiography (TTE) with dedicated software for measuring the RA strain (RAS). RA function is thus divided into three phases: reservoir (RASr), conduit, and contraction. Numerous studies have demonstrated that a significant alteration in RAS predicts POAF in various clinical contexts. Therefore, it is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery.

It is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery.

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Key information

Conditions

Postoperative Atrial Fibrillation Sprains and Strains Strains Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Amiens Picardie

Amiens, France

Location status: Recruiting

Location contact

Camille DAUMIN, MD

CONTACT

[email protected]

03 22 08 77 95

Christophe Beyls, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patient (>18 years old)
The patient was hospitalized at the Amiens University Hospital for scheduled aortocoronary bypass grafting under cardiopulmonary bypass.
Echocardiographic image quality enabling the measurement of RAS parameters
Patient affiliation to a social security scheme
Patient/proxy information and collection of their non-opposition.

Exclusion criteria

Patients participating in an interventional study may modify the incidence of POAF.
History of atrial fibrillation or flutter.
Valvular and ascending aorta cardiac surgery
Urgent cardiac surgery.
Presence of tricuspid insufficiency greater than grade 2.
Left ventricular ejection fraction lower than 50%.
Patient receiving circulatory mechanical assistance before surgery.
Dependency on ventricular and atrial pacing by an internal or external cardiac pacemaker during the echocardiographic examination.

Treatment and study plan

Primary outcomes

Correlation of RASr parameter variation with POAF incidence

Time frame: 30 months

Correlation of RASr parameter variation with POAF incidence in patients undergoing postoperative cardiac surgery

Study contacts

Contact information is provided by the study sponsor or research team.

Camille DAUMIN, MD

CONTACT

[email protected]

03 22 08 77 95

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: ODFAPO

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2026
First posted: Sep 26, 2023
Registry last updated: May 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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