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OpenTrials
Completed

NCT Number: NCT02871544

Predictive Value of Dynamic Combination of BNP and NGAL for the Prognosis of Patients With Sepsis

Objective: to clarify the predictive value of brain natriuretic peptide (BNP) in combination with neutrophil gelatinase associated lipocalin (NGAL) for the prognosis of patients with sepsis.

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Key information

Conditions

28-day Mortality Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age ≥18 years and <85 years;
  • presence of severe sepsis according to Survival Sepsis Campaign 10;
  • all patients voluntarily joined this study with informed consents.

Exclusion criteria

  • participated in other trials within 30 days before the criteria for this trial were met;
  • expected to die within 24 hours;
  • pregnant;
  • advanced malignancy with life expectancy <6 months;
  • history of congestive heart failure;
  • chronic renal dysfunction (baseline creatinine >176.8μmol/L); and
  • relatives were unwilling to agree to the use of full life support.

Treatment and study plan

BNP and NGAL

Other

Primary outcomes

  1. patient-ventilator synchrony for 30mins

    Time frame: 30mins after the patients involved

Secondary outcomes

  1. the numbers of days in the ICU between day 1 and day 28

    Time frame: the numbers of days in the ICU until day 28

  2. Mechanical ventilation duration between day 1 and day 28

    Time frame: days of mechanical ventilation between day 1 and day 28

  3. 28-day mortality

    Time frame: 28 days after the patients involved

Sponsors and collaborators

Lead sponsor

Southeast University, China

Other

Registry information

Official study title

Predictive Value of Dynamic Combination of B-type Natriuretic Peptide and Neutrophil Gelatinase-associated Lipocalin for the Prognosis of Patients With Sepsis

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Aug 18, 2016
Registry last updated
Aug 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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