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NCT Number: NCT07445217

Predictive Validity of the Personal and Social Performance Scale for PANSS Outcomes in Schizophrenia

The Positive and Negative Syndrome Scale (PANSS) is a widely used instrument for assessing symptom severity in schizophrenia, whereas the Personal and Social Performance Scale (PSP) provides a practical measure of functional outcomes. This study aimed to evaluate the predictive validity of the PSP for PANSS outcomes in individuals with schizophrenia.

A total of 763 patients diagnosed with schizophrenia and receiving paliperidone treatment were recruited in a 12-week multicenter prospective study. Among participants with a baseline PANSS score greater than 90, those with a 12-week PSP score above 60 were more likely to achieve a reduction of more than 20% in PANSS scores, whereas those with a PSP score below 60 showed less improvement.

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Key information

Conditions

Functional Outcomes Mental Disorders Schizophrenia Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Calo Psychiatric Center

Pingtung City, 925, Taiwan

About this study

This study employed a 12-week, multicenter, prospective research design focusing on the administration of the antipsychotic medication paliperidone. Assessments were conducted at baseline, week 4, and week 12. Two widely used scales-the PANSS and PSP-were utilized to evaluate patients before and after treatment, followed by a correlation analysis of the results.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • criteria diagnosis of schizophrenia

Exclusion criteria

  • schizoaffective disorder
  • severe major depressive disorder
  • bipolar disorder
  • substance use disorders
  • organic brain conditions

Treatment and study plan

This study employed a 12-week, multicenter, prospective research design focusing on the administration of the antipsychotic medication paliperidone.

Drug

Assessments were conducted at baseline, week 4, and week 12. Two widely used scales-the PANSS and PSP-were utilized to evaluate patients before and after treatment, followed by a correlation analysis of the results.

Primary outcomes

  1. the gender different in the effect of paliperidone treatment in schizophrenia

    Time frame: The differences were evaluated before treatment, and week 4 and week 12 after treatment.

    The difference of paliperidone treatment between males and females were explored at baseline, week 4, and week 12.

Secondary outcomes

  1. The PANSS responses in schizophrenia with paliperidone

    Time frame: The responses of PANSS were evaluated before the treatment, and week 4 and week 12 after treatment

    The Positive and Negative Syndrome Scale (PANSS) was utilized to evaluate the symptom improvment in individuals undergoing antipsychotic treatment. PANSS scores below 58 indicatemild symptoms, higher scores indicate more severe symptoms.

Other outcomes

  1. The predictive validity of the PSP for PANSS outcomes in schizophrenia

    Time frame: PSP was utilized to evaluate patients before treatment, and week 4 and week 12 after treatment.

    To explore the Personal and Social Performance Scale (PSP) as a practical and efficient tool for monitoring treatment response and functional outcomes in schizophrenia, or not. The scores of PSP with higher scores indicate higher functional recovery.

Sponsors and collaborators

Lead sponsor

Calo Psychiatric Center

Other

Registry information

Official study title

Predictive Validity of the Personal and Social Performance Scale for PANSS Outcomes in Schizophrenia: a Severity-stratified Study

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Mar 3, 2026
Registry last updated
Mar 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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