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NCT Number: NCT07536607

Predictive Role of Photon Counting Computed Tomography in Acute Coronary Syndrom Patients

For patients with severe calcification or complex non-calcified plaques, we investigate wether PCCT can enable non-invasive, in vivo precise differentiation and quantitative measurement of plaque components (e.g., spotty calcification, necrotic core, fibrous tissue). Further we also study wether these quantitative imaging features can independently predict the risk of MACE in the short term and long term

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chinese PLA General Hospital

Beijing, China

About this study

Photon-counting detector CT (PCD-CT), as an innovative technology in the field of CT imaging, is gradually transforming the landscape of cardiac imaging. It differs significantly from conventional energy-integrating detector CT (EID-CT) in technical principles, bringing new possibilities for the diagnosis and assessment of heart diseases. This study will enrolled patients undergo standardized PCCT coronary angiography (CCTA) and make ultra-fine quantitative plaque analysis. Then at least 12 months of clinical follow-up will be performed. Finally correlation analysis between baseline plaque characteristics and follow-up endpoint events will be made.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion Criter:

  • Adult patients (≥18 years) with clinically diagnosed coronary artery disease or undergoing CCTA for chest pain/heart failure symptoms.
  • Able and willing to provide informed consent and complete scheduled follow-up visits.

Exclusion criteria

  • History of iodine contrast agent allergy.
  • Severe renal insufficiency (eGFR < 30 mL/min/1.73 m²).
  • History of prior coronary artery bypass grafting (CABG).
  • Pregnant or lactating women

Treatment and study plan

There is no intervention in this study

Other

there is no intervention

Primary outcomes

  1. Major Adverse Cardiovascular Events, MACE

    Time frame: 12months

    Non-fatal myocardial infarction Non-fatal stroke Cardiovascular death Revascularization Acute heart failure

Study contacts

Contact information is provided by the study sponsor or research team.

jing ma, PhD, MD, PhD,MD

CONTACT

[email protected]

+86 13681257396

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Official study title

Prospective Study ofPhoton Counting Computed Tomography in Acute Coronary Syndrom Patients

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Apr 17, 2026
Registry last updated
Apr 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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