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NCT Number: NCT07122856

Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients

This study looks at people with Alzheimer's disease to find out which factors are linked to their initial score on the Mini-Mental State Examination (MMSE) and which factors may predict a fast decline in their score over 12 months. Researchers will review medical records from patients seen at the Memory Clinic of Gonesse Hospital and analyze information such as age, education, medical history, nutrition, mood, and caregiver burden. The goal is to better understand what influences early cognitive performance and how quickly it changes, to help improve patient care and planning.

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Key information

Conditions

Alzheimer Disease Brain Diseases Caregivers Central Nervous System Diseases Cognition Disorders Cognitive Dysfunction Dementia Mental Disorders Mini-Mental State Examination Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Neuropsychological Tests Tauopathies

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Confirmed diagnosis of Alzheimer's disease according to NIAA 2018 or IWG 2021 criteria
  • At least two MMSE evaluations spaced 12 months apart
  • Follow-up at the Memory Clinic of CH Gonesse

Exclusion criteria

  • Presence of other neurodegenerative diseases (e.g., Frontotemporal Dementia, Multiple System Atrophy, Vascular Dementia, LATE)
  • Patient has moved out of the study area (outside the CH Gonesse territory)

Treatment and study plan

Primary outcomes

  1. Change in MMSE Score Over 12 Months - measured as either a decrease of ≥3 points on the Mini-Mental State Examination [MeSH] or patient institutionalization within 12 months.

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

Centre Hospitalier de Gonesse

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 14, 2025
Registry last updated
Aug 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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