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NCT Number: NCT02302482

Predictive Factors and Autonomy Level Change

The Alzheimer's disease or related disorders (ADRD) are among the most disabling diseases because of their main features such as cognitive impairment, loss of functional autonomy and behavioural disorders. In absence of current curative treatment, the identification of the predictive risk factors of progression of the disease, evaluated through its main symptoms, represents a major stake of public health. The investigators aimed at developing a database, which includes the patient medical records on a prospective basis, in collaboration with the medical and administrative personal and with the University hospital computer science department. The main objective is to study the predictive factors associated with the change of functional autonomy level, measured every 6 months to 12 months by phone, in a Memory Clinic. The study population would consist in about 1000 patients with ADRD. The length of follow-up of each patient will be 3 years.

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Key information

Conditions

Memory Impairment Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Memory Disorders Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Tauopathies

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Dugoujon, Caluire-et-Cuire, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who undergo a medical visit in the Memory Clinic for the 1st time
  • Patients living at home or in housing
  • Patients with memory impairment, at all stage of the disease

Exclusion criteria

  • Patients in institution
  • Patients under legal protection
  • Patients with a hearing or visual impairment, which dot not allow to carry out the examination

Treatment and study plan

The Lawton Instrumental Activities of Daily Living score (IADL), and the disability assessment of dementia score (DAD-6

Other

Primary outcomes

  1. Functional autonomy level

    Time frame: 3 years

    The scores of "Lawton Instrumental Activities of Daily Living" (IADL) and of "Disability Assessment of Dementia" (DAD-6)

Secondary outcomes

  1. Cognitive function level

    Time frame: 3 years

    Mini Mental Test examination (MMSE)

Study contacts

Contact information is provided by the study sponsor or research team.

Pierre Krolak-Salmon, Professor

CONTACT

[email protected]

(0)4 72 43 20 50 ext. +33

Virginie Dauphinot, Doctor

CONTACT

[email protected]

(0)4 72 43 20 50 ext. +33

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Predictive Factors of the Autonomy Level Change Related to Memory Disorders

Acronym: MEMORA

Important dates

Study start
2014
Primary completion
2027
Study completion
2027
First posted
Nov 27, 2014
Registry last updated
Jun 28, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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