Predictive Effect of TGF-β and INS-PI3K-AKT Related Proteins for POD in Diabetes Patients

The study was a two-center, prospective，single blind (blinded to subjects and evaluators)，control, observational clinical study. Participants will collect 3 milliliters of blood from enrolled patients before surgery begins. The collected blood samples were processed and stored in -80℃ refrigerator. All samples were tested TGF-β and INS-PI3K-AKT signaling pathway related proteins (ADNP, MAP6, PGC-1α) by ELISA.

Inclusion criteria

• Age ≥65 years
• History of diabetes ≥2 years and Glycated hemoglobin ≥6.5% or no history of diabetes and normal blood glucose
• The ASA rating is Class I to III
• The elderly patients of limited thoracic and abdominal tumor surgery

Exclusion criteria

• Refused to participate
• Previous history of schizophrenia, epilepsy, Parkinson's disease
• History of alcohol abuse or drug dependence
• Patients with ASA grade IV and above
• Severe visual or hearing impairment, can not cooperate with the completion of cognitive function tests
• Participants in other clinical trials within the last two months
• Patients with severe arrhythmia or cardiac dysfunction(EF<40%)
• There was a clear history of neurological and psychiatric problems or long-term use of sedatives or antidepressants
• History of cerebrovascular disease or brain surgery or trauma
• Severe liver dysfunction (Child-Pugh class C) or severe renal dysfunction (requiring dialysis)