PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin

The goal of this observational study is to know if, in patients with acute kidney injury, naive for renal injurie, admitted to different ICUs, the change in plasma concentration of c-cistatin, between initiation and discontinuation of CRRT, is a predictive finding to optimize the withdrawal time of renal support

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

IRCCS Azienda Ospedaliero-Universitaria di Bologna - Anestesia e Terapia Intensiva nelle emergenze locali, regionali e nazionale e nella chirurgia addominale maggiore, Bologna, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age ≥ 18 years;
diagnosis of acute kidney injury (defined according to KDIGO 2012 criteria)
need for support with CRRT according to the indications of the nephrologist consultants and Clinical Practice
Obtaining informed consent

Exclusion criteria

CRRT already ongoing (in another department not participating in the study) at the time of transfer/admission to intensive care;
need for RRT (any type and modality) in the 14 days prior to enrolment;
diagnosis of AKD/CKD/ESRF on admission;
Discontinuation of CRRT under conditions that do not comply with the criteria established by the study;
Need for CRRT not associated with AKI condition (e.g. elimination of toxicants);
pregnant women;
presence of known thyreopathy
Continuous use of corticosteroids
patient with known neoplastic disease.

Treatment and study plan

Primary outcomes

the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU

Time frame: From enrlollment to the weaning from CRRT and 14 days after

To verify whether the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU It is measured as (cistatin at weaning minus cistatin basal) divided by cistatine basal, in percentage

Study contacts

Contact information is provided by the study sponsor or research team.

Francesco Marino, MD

CONTACT

[email protected]

3293842166

Sponsors and collaborators

Lead sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Other

Registry information

Acronym: PRESSING

Important dates

Study start: 2024
Primary completion: 2026
Study completion: 2026
First posted: Dec 3, 2024
Registry last updated: Dec 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting