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NCT Number: NCT07188636

Prediction of Postoperative Mortality in Patients Undergoing Non-cardiac Surgery: Development and Validation of the Surgical Mortality Model

This study aims to develop and validate a simple, accurate model to predict mortality after non-cardiac surgery.

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Key information

Conditions

Mortality Prediction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Asan Medical Center, University of Ulsan College of Medicine

Seoul, 05505, South Korea

About this study

This retrospective multi-center cohort study aimed to develop and externally validate a predictive model for postoperative mortality in adult patients undergoing non-cardiac surgery. The development cohort included patients from Asan Medical Center, and validation was performed using data from Seoul National University Hospital and Samsung Medical Center. Mortality was assessed at 30 days, 180 days, 1 year, and overall follow-up. The model was developed using LASSO logistic regression and evaluated for discrimination and calibration across cohorts.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years or older who underwent non-cardiac surgery

Exclusion criteria

  • Patients who underwent obstetric surgeries
  • Transplant donors and recipients
  • Patients with incomplete data or missing laboratory values

Treatment and study plan

No Intervention: Observational Cohort

Other

Participants underwent non-cardiac surgery and were followed retrospectively without any experimental intervention. Data were collected from electronic medical records and national death registry to assess postoperative mortality outcomes.

Primary outcomes

  1. 30-day postoperative mortality

    Time frame: Up to 30 days after surgery

    Death from any cause occurring within 30 days after non-cardiac surgery, ascertained from hospital records and national death registry data.

Secondary outcomes

  1. 180-day postoperative mortality

    Time frame: Up to 180 days after surgery

    Death from any cause within 180 days after non-cardiac surgery.

  2. 1-year postoperative mortality

    Time frame: Up to 1 year after surgery

    Death from any cause within 365 days after non-cardiac surgery.

  3. Overall postoperative mortality

    Time frame: Through study completion (median follow-up: approximately 5 years, maximum: 13 years)

    Death from any cause during the entire follow-up period after non-cardiac surgery.

Sponsors and collaborators

Lead sponsor

Asan Medical Center

Other

Registry information

Official study title

Development and Validation of the Surgical Mortality Model for Predicting Postoperative Mortality in Non-cardiac Surgery: A Retrospective Multi-center Cohort Study

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Sep 23, 2025
Registry last updated
Sep 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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