Prediction of Jaundice in Term Infants

The objective of this study was to describe total bilirubin production in healthy term infants as a means of understanding the differences in jaundice pigment production associated with various common clinical circumstances.

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Key information

Conditions

Infant, Newborn Hyperbilirubinemia Jaundice Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Manifestations

Age range

Up to 8 hour

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University, Palo Alto, California, United States

About this study

Jaundice occurs in most human neonates during the several days after birth. The objective of this study was to describe total bilirubin production in healthy term infants as a means of understanding the differences in jaundice pigment production associated with various common clinical circumstances.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Infants born via cesarean delivery (to ensure subjects would still be hospitalized and available for ETCOc measurement and blood sampling on day 3 postpartum)
Delivery within each center's scheduled recruitment period (to maximize nursing availability and minimize cost)
Birth weight >2500 g
Gestational age >37 weeks

Exclusion criteria

Any illness that would require admission to the neonatal intensive-care unit (NICU) within 8 hours of birth

Treatment and study plan

Primary outcomes

End-tidal carbon End-tidal carbon monoxide levels corrected for ambient air (ETCOc)

Time frame: 2-8 hours of age

An index of bilirubin production

Sponsors and collaborators

Lead sponsor

NICHD Neonatal Research Network

Network

Registry information

Official study title

BilirubinProduction in Healthy Term Infants as Measured by Carbon Monoxide in Breath

Important dates

Study start: 1991
Primary completion: 1992
Study completion: 1992
First posted: Sep 16, 2010
Registry last updated: Mar 22, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed