Prediction of Inspiratory Effort Response to High PEEP in Patients Recovering From ARDS

Spontaneous Breathing (SB) can be potentially harmful in patient with Acute Respiratory Distress Syndrome (ARDS) during the transition phase of passive ventilation to partial ventilatory support. A high respiratory drive and consequently, a strong inspiratory effort, may produce large transpulmonary pressure (TP) swings mainly in dependent lung regions closer to the diaphragm and cause alveolar rupture and inflammatory mediators release.

The application of high Positive End Expiratory Pressure (PEEP) during SB has shown to ameliorate the progression of lung injury by decreasing the TP and esophageal pressure (EP) swings and the stress / strain applied to the lung. However, it is uncertain which patient will respond adequately to the application of high PEEP and consequently will reduce the inspiratory effort.

Recent evidence suggests that high PEEP may confer protective effects when lung compliance improves. However, assessing lung compliance at the bedside is challenging, as it requires esophageal pressure monitoring. Simpler tools to identify lung compliance response to PEEP are neccesary.

Preclinical data suggest that the changes in compliance are followed by opposite changes in respiratory rate (RR) - i.e., if compliance improves, RR decreases and vicerversa. However, if this behaviour is also observed in ARDS patients ventilated at different PEEP levels is unkown. Additionally, whether changes in RR can be useful to identify changes in lung compliance when increasing PEEP has never been tested.

Inclusion criteria

• Need of invasive mechanical ventilation
• Patients who had fulfill ARDS criteria based on Berlin definition during any time of invasive mechanical ventilation.
• Patient ventilated in pressure support ventilation.
• Time of invasive ventilation expected to be longer than 24 hs after the day of enrollment.

Exclusion criteria

• Neuromuscular diseases (e.g., amyotrophic lateral sclerosis, Duchenne Erb)
• previous diagnosis of chronic obstructed pulmonary disease
• not resolved pneumothorax
• bronchopleural fistula
• suspicion of central respiratory drive alteration (e.g., benzodiazepines intoxication).