Prediction of Hemodynamic Reactivity During General Anesthesia Using Analgesia/Nociception Index (ANI)

The aim of this study is to evaluate the performance of Analgesia/Nociception Index for the prediction of hemodynamic reactivity in adult patients undergoing ear-nose-throat or lower limb orthopedic surgery on desflurane/remifentanil general anesthesia.

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Key information

Conditions

Anesthesia Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Édouard Herriot, HCL

Lyon, Rhône, 69003, France

About this study

Measurement of analgesia/nociception index at different time points during procedure and assessment of analgesia/nociception index to predict hemodynamic reactivity by building receiver observer's characteristic curve.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18-75 years
Ear-nose-throat or lower limb surgery
General anesthesia using desflurane and remifentanil

Exclusion criteria

Age <18 yrs or >75 yrs
Arrythmia
Preoperative use of B-blockers
Administration of anticholinergic drugs or neuromuscular blockade reversal in the 20 previous minutes
Psychiatric diseases
Autonomic nervous system disorders (epilepsy)

Treatment and study plan

Primary outcomes

Change in heart rate and/or systolic blood pressure by more than 20% within 5 minutes

Time frame: Before induction of anesthesia, 1 min after incision, at steady-state anesthesia during procedure (an expected average of 30 min) and at arousal from general anesthesia in the end of procedure (an expected average of 60 min)

Sponsors and collaborators

Lead sponsor

Hôpital Edouard Herriot

Other

Registry information

Official study title

Prediction of Hemodynamic Reactivity During Desflurane/Remifentanil General Anesthesia Using Analgesia/Nociception Index (ANI)

Important dates

Study start: 2013
Primary completion: 2013
Study completion: 2013
First posted: Apr 25, 2013
Registry last updated: Nov 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed