Children's Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400010, China
Completed
NCT Number: NCT06045949
Prediction of Early Recovery of Liver Function After LDLT in Children: An Ambispective Cohort Study
The investigators included children with living donor liver transplantation (LDLT) from January 1, 2018 to July 31, 2022 as a retrospective cohort, and the group from August 1, 2022 to June 30, 2023 as a prospective cohort. The investigators collected the demographic and clinicopathological data of donors and recipients, and determined the risk factors of early postoperative delayed recovery of hepatic function (DRHF) by univariate and multivariate Logical regression analyses.
Completed
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Conditions
Age range
0 year–18 year
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- children with the indication of LDLT [cholestatic liver disease (such as BA), metabolic liver disease (such as Wilson's disease and Ornithine transcarbamylase deficiency), acute liver failure (such as drug induced), neoplastic disease (such as hepatoblastoma), vascular disease (such as cavernous transformation of portal vein and congenital absence of portal vein), re-transplantation and others];
- the relatives of the children voluntarily donated part of the liver which met the requirements of LDLT.
Exclusion criteria
- recipients with contraindications of LDLT (such as coagulation dysfunction, acute infection, cardiopulmonary failure);
- failure to complete LDLT due to various reasons (such as death during or within 3 days after operation);
- recipients or donors with incomplete necessary data.
Treatment and study plan
Primary outcomes
-
DRHF
Time frame: 30 days after LDLT in children
Investigators collected liver function data of children after LDLT. Delayed recovery of hepatic function (DRHF) is characterized by the increase of PT-INR combined with hyperbilirubinemia on or after postoperative day 5.
Sponsors and collaborators
Lead sponsor
Huiwu Xing
Other
Registry information
Official study title
Prediction of Early Recovery of Liver Function After Living Donor Liver Transplantation in Children: An Ambispective Cohort Study
Important dates
- Study start
- 2022
- Primary completion
- 2023
- Study completion
- 2023
- First posted
- Sep 21, 2023
- Registry last updated
- Sep 21, 2023
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.