Prediction of Duration of Mechanical Ventilation in Acute Hypoxemic Respiratoty Failure

Acute hypoxemic respiratory failure (AHRF) is the most common cause of admission in intensive care units (ICUs) worldwide. The investigators will assess the value of machine learning (ML) techniques for prediction of prolonged duration (> or equeal to 7 days) of mechanical ventilation (MV) in 1,241 patients enrolled in the PANDORA study in Spain. Few studies have investigated the prediction of prolonged MV in patients with AHRF.

For model training and testing, the investigators will extract data from random pateints from the first 2 days after diagnosis of AHRF. The investigators had a database with 2,000,000 anonymized and dissociated demographics and clinically relevant data from 1,241 patients with AHRF from 22 hospitals in Spain. The investigators will follow the TRIPOD guidelines for prediction models. The investigators will screen relevant collected variables using a genetic algorithm variable selection to achieve parsimony. We will use 5-fold corss-validation in the data set of patients with data at T0, T24 and T48. We will use 25% of patients randomly selected for evaluation of the model.

Inclusion criteria

• enotracheal intubation puls mechanical ventilation
• PaO2/FiO2 ratio <or = 300 mmHg under MV with PEEP >or =5 and FiO2 >or = 0.3

Exclusion criteria

• Brain death patients